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- W3023218993 abstract "Endometriosis is an estrogen-dependent disease, which affects 10% of women in the reproductive age. Malignant transformation is an uncommon event, which affects approximately 0.7-2.5% of women, and, when it occurs, it involves ovarian and extraovarian sites in 75% and 25% of the cases, respectively. Endometriosis correlates with presentation of clear cell and endometrioid carcinoma of the ovary. Activation of phosphatidylinositol 3-kinase (PIK3) – protein kinase B (AKT) – mammalian target of rapamycin (mTOR) pathway, aberrant chromatin remodeling due to AT-rich interactive domain-containing protein 1A (ARID1A) mutation and inactivation of estrogen receptor-α signaling seem to play a major role in the carcinogenesis. To date, little data are available regarding endometriosis-associated extraovarian malignancies. The aim of the present study was to review the clinical, pathological and prognostic features of endometriosis-related neoplasms arising from extraovarian sites, with particular focus on intestinal malignancies, urinary tract malignancies and tumors arising from surgical scars." @default.
- W3023218993 created "2020-05-13" @default.
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- W3023218993 date "2020-05-01" @default.
- W3023218993 modified "2023-10-07" @default.
- W3023218993 title "Endometriosis-associated Extraovarian Malignancies: A Challenging Question for the Clinician and the Pathologist" @default.
- W3023218993 doi "https://doi.org/10.21873/anticanres.14212" @default.
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