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- W3023222022 abstract "Herein, we report the synthesis and the multiple anti-tumor properties of new gold and silver carbene complexes. The chemical modifications, grounded on our previous studies, led us to identify a good lead complex, gold-based, whose biological features are very exciting and promising in the anti-cancer research and could be further developed. Indeed, the bis-[4,5-dichloro-(N-methyl-N’(2-hydroxy-2-phenyl)ethyl-imidazole-2-ylidene)gold(I)]+[dichloro-gold]− (AuL7) complex possesses the ability to interfere with at least three important and different intracellular targets, namely the human topoisomerases I and II and tubulin, which are able to modulate metabolic processes not directly correlated each other. We proved that the modifications of the ligands structure in AuL7, with respect to another already published complex, i.e., bis-[4,5-dichloro-(N-methyl-N’(cyclopentane-2ol)-imidazole-2-ylidine)gold(I)]+[dichloro-gold]− (AuL4), produce a different behavior toward tubulin-polymerization process, since AuL7 is a tubulin-polymerization inhibitor and AuL4 a stabilizer, with the final same result of hampering the tumor growth. Taken together, our outcomes designate AuL7 as a promising compound for the development of multi-targeted anti-cancer therapies." @default.
- W3023222022 created "2020-05-13" @default.
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- W3023222022 date "2020-05-11" @default.
- W3023222022 modified "2023-10-06" @default.
- W3023222022 title "Is the Way to Fight Cancer Paved with Gold? Metal-Based Carbene Complexes with Multiple and Fascinating Biological Features" @default.
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- W3023222022 doi "https://doi.org/10.3390/ph13050091" @default.
- W3023222022 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7281280" @default.
- W3023222022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32403274" @default.
- W3023222022 hasPublicationYear "2020" @default.
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