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- W3023226849 abstract "You have accessJournal of UrologyProstate Cancer: Detection & Screening III (PD38)1 Apr 2020PD38-07 PROMPT – PROSTATE GENETIC SCORE IMPROVES THE PERFORMANCE OF ESTABLISHED PROSTATE CANCER RISK CALCULATORS Fady Ghali*, Stephen Ryan, Donna Ankerst, Michael Kattan, and Andrew Kader Fady Ghali*Fady Ghali* More articles by this author , Stephen RyanStephen Ryan More articles by this author , Donna AnkerstDonna Ankerst More articles by this author , Michael KattanMichael Kattan More articles by this author , and Andrew KaderAndrew Kader More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000917.07AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Prostate cancer (PCa) risk calculators outperform provider intuition in predicting PCa at time of biopsy. We sought to investigate the impact of adding Prompt – Prostate genetic score (PGS), a germline genetic risk stratification tool, on the performance of established PCa risk calculators. METHODS: Prompt-PGS is a genetic score that weights odds ratios of PCa-associated SNPs per previous publications. Data from placebo arm participants with DNA available from the PCa Prevention Trial (PCPT) and REDUCE were used to assess the incremental value in PCa detection of incorporation of the Prompt-PGS to the standard clinical risk factors used in the online PCPT and Prostate Biopsy Collaborative Group (PBCG) risk tools. Validation performance was quantified by discrimination measured by the area under the ROC curve (AUC), calibration visualized by observed versus expected risk plots, and combined discrimination-calibration accuracy quantified by the index of prediction accuracy (IPA). RESULTS: A total of 4870 patients from PCPT and 1643 patients from REDUCE had complete demographic and genotype data and were included in the analysis included in the analysis. The AUC and IPA of both the PCPT and PBCG risk tools were improved by including Prompt-PGS for both the PCPT and PBCG populations (Table 1). Observed versus expected plots (Figure 1) revealed superior calibration of inclusion of the Prompt-PGS score compared to either risk tool alone in both the PCPT and REDUCE populations, particularly on the lower end of risk. CONCLUSIONS: A germline-genetic risk stratification tool, Prompt – PGS, improves the performance of both the PCPT and PBCG risk tools in two large populations, particularly at the lower end of risk. It may be a useful tool for safely decreasing unnecessary prostate biopsies. Source of Funding: N/A © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e803-e804 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Fady Ghali* More articles by this author Stephen Ryan More articles by this author Donna Ankerst More articles by this author Michael Kattan More articles by this author Andrew Kader More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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- W3023226849 date "2020-04-01" @default.
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- W3023226849 title "PD38-07 PROMPT – PROSTATE GENETIC SCORE IMPROVES THE PERFORMANCE OF ESTABLISHED PROSTATE CANCER RISK CALCULATORS" @default.
- W3023226849 doi "https://doi.org/10.1097/ju.0000000000000917.07" @default.
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