FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023235526> ?p ?o ?g. }

• W3023235526 endingPage "1880" @default.
• W3023235526 startingPage "1871" @default.
• W3023235526 abstract "Gene specific recruitment of bromodomain-containing proteins to chromatin is affected by post-translational acetylation of lysine on histones. Whereas interactions of the bromodomain with acetylation patterns of native histones (H2A, H2B, H3, and H4) have been well characterized, the motif for recognition for histone variants H2A.Z I and H2A.Z II by bromodomains has yet to be fully investigated. Elucidating these molecular mechanisms is crucial for understanding transcriptional regulation in cellular processes involved in both development and disease. Here, we have used protein-observed fluorine NMR to fully characterize the affinities of H2A.Z I and II acetylation patterns for BPTF’s bromodomain and found the diacetylated mark of lysine 7 and 13 on H2A.Z II to have the strongest interaction with K7ac preferentially engaging the binding site. We further examined the selectivity of H2A.Z histones against a variety of bromodomains, revealing that the bromodomain of CECR2 binds with the highest affinity and specificity for acetylated H2A.Z I over isoform II. These results support a possible role for different H2A.Z transcriptional activation mechanisms that involve recruitment of chromatin remodeling complexes." @default.
• W3023235526 created "2020-05-13" @default.
• W3023235526 creator A5017304539 @default.
• W3023235526 creator A5022400340 @default.
• W3023235526 creator A5024223427 @default.
• W3023235526 creator A5027272580 @default.
• W3023235526 creator A5037316027 @default.
• W3023235526 creator A5044660040 @default.
• W3023235526 creator A5049546274 @default.
• W3023235526 creator A5053066800 @default.
• W3023235526 creator A5067835342 @default.
• W3023235526 creator A5082680293 @default.
• W3023235526 date "2020-05-01" @default.
• W3023235526 modified "2023-10-17" @default.
• W3023235526 title "NMR Analyses of Acetylated H2A.Z Isoforms Identify Differential Binding Interactions with the Bromodomain of the NURF Nucleosome Remodeling Complex" @default.
• W3023235526 cites W1515955839 @default.
• W3023235526 cites W1978431886 @default.
• W3023235526 cites W1991343966 @default.
• W3023235526 cites W1996707370 @default.
• W3023235526 cites W2001322117 @default.
• W3023235526 cites W2002698073 @default.
• W3023235526 cites W2003475800 @default.
• W3023235526 cites W2003872705 @default.
• W3023235526 cites W2007639313 @default.
• W3023235526 cites W2007916651 @default.
• W3023235526 cites W2013571070 @default.
• W3023235526 cites W2015681476 @default.
• W3023235526 cites W2032969093 @default.
• W3023235526 cites W2033856541 @default.
• W3023235526 cites W2035630029 @default.
• W3023235526 cites W2036792320 @default.
• W3023235526 cites W2039564969 @default.
• W3023235526 cites W2039597909 @default.
• W3023235526 cites W2070835225 @default.
• W3023235526 cites W2071049584 @default.
• W3023235526 cites W2076283593 @default.
• W3023235526 cites W2080577763 @default.
• W3023235526 cites W2082837622 @default.
• W3023235526 cites W2087573417 @default.
• W3023235526 cites W2098952156 @default.
• W3023235526 cites W2106134616 @default.
• W3023235526 cites W2106940478 @default.
• W3023235526 cites W2114763268 @default.
• W3023235526 cites W2121169582 @default.
• W3023235526 cites W2123647733 @default.
• W3023235526 cites W2133338884 @default.
• W3023235526 cites W2144792857 @default.
• W3023235526 cites W2157099146 @default.
• W3023235526 cites W2167197669 @default.
• W3023235526 cites W2171630274 @default.
• W3023235526 cites W2211128291 @default.
• W3023235526 cites W2261819980 @default.
• W3023235526 cites W2296375307 @default.
• W3023235526 cites W2460757626 @default.
• W3023235526 cites W2520238551 @default.
• W3023235526 cites W2559776465 @default.
• W3023235526 cites W2596097823 @default.
• W3023235526 cites W2744691030 @default.
• W3023235526 cites W2759095162 @default.
• W3023235526 cites W2791304015 @default.
• W3023235526 cites W2796783475 @default.
• W3023235526 cites W2914035046 @default.
• W3023235526 cites W2951529323 @default.
• W3023235526 cites W2971994668 @default.
• W3023235526 cites W2988931838 @default.
• W3023235526 doi "https://doi.org/10.1021/acs.biochem.0c00159" @default.
• W3023235526 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7771244" @default.
• W3023235526 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32356653" @default.
• W3023235526 hasPublicationYear "2020" @default.
• W3023235526 type Work @default.
• W3023235526 sameAs 3023235526 @default.
• W3023235526 citedByCount "10" @default.
• W3023235526 countsByYear W30232355262020 @default.
• W3023235526 countsByYear W30232355262021 @default.
• W3023235526 countsByYear W30232355262022 @default.
• W3023235526 countsByYear W30232355262023 @default.
• W3023235526 crossrefType "journal-article" @default.
• W3023235526 hasAuthorship W3023235526A5017304539 @default.
• W3023235526 hasAuthorship W3023235526A5022400340 @default.
• W3023235526 hasAuthorship W3023235526A5024223427 @default.
• W3023235526 hasAuthorship W3023235526A5027272580 @default.
• W3023235526 hasAuthorship W3023235526A5037316027 @default.
• W3023235526 hasAuthorship W3023235526A5044660040 @default.
• W3023235526 hasAuthorship W3023235526A5049546274 @default.
• W3023235526 hasAuthorship W3023235526A5053066800 @default.
• W3023235526 hasAuthorship W3023235526A5067835342 @default.
• W3023235526 hasAuthorship W3023235526A5082680293 @default.
• W3023235526 hasBestOaLocation W30232355262 @default.
• W3023235526 hasConcept C104317684 @default.
• W3023235526 hasConcept C119157956 @default.
• W3023235526 hasConcept C167227067 @default.
• W3023235526 hasConcept C185592680 @default.
• W3023235526 hasConcept C24284526 @default.
• W3023235526 hasConcept C2776016237 @default.
• W3023235526 hasConcept C2779634854 @default.
• W3023235526 hasConcept C515207424 @default.
• W3023235526 hasConcept C53345823 @default.
• W3023235526 hasConcept C55493867 @default.

• next