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- W3023302803 endingPage "1725" @default.
- W3023302803 startingPage "1711" @default.
- W3023302803 abstract "The discovery of immune checkpoints and their role in modulating immune response have revolutionised cancer treatment in recent years. The immune checkpoints, cytotoxic T‐lymphocyte‐associated protein 4, programmed cell death protein 1 and its ligand, programmed cell death‐ligand 1, have been extensively studied. Currently 7 monoclonal antibodies targeting these immune checkpoints are approved for treatment of various cancers. Inhibiting immune checkpoints has shown some success in clinic, however, a proportion of patients do not benefit from this treatment. Several other inhibitory molecules, in addition to lymphocyte‐associated protein 4 and programmed cell death protein 1, are known to be involved in regulating immune response. To further improve patient outcomes, studies have examined targeting these inhibitory molecules through combination therapies. This review discusses the current landscape of combination therapies of checkpoint inhibitors." @default.
- W3023302803 created "2020-05-13" @default.
- W3023302803 creator A5027726048 @default.
- W3023302803 creator A5041888746 @default.
- W3023302803 creator A5069930086 @default.
- W3023302803 date "2020-06-18" @default.
- W3023302803 modified "2023-09-26" @default.
- W3023302803 title "Scientifically based combination therapies with immuno‐oncology checkpoint inhibitors" @default.
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