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- W3023340384 abstract "Gastrointestinal stromal tumors (GIST) are rare neoplasms of mesenchymal origin arising in the gastrointestinal tract. The vast majority are characterized by mutually exclusive activating mutations in KIT or Platelet-derived growth factor alpha (PDGFRA) receptors, or less frequently by succinate dehydrogenase complex (SDH) or NF1 inactivation, with very rare cases harboring mutant BRAF or RAS alleles. Approximately 5% of GISTs lack any of such mutations and are called quadruple wild-type (WT) GISTs. Recently, deregulated Fibroblast Growth Factor (FGF)/FGF-receptor (FGFR) signaling emerged as a relevant pathway driving oncogenic activity in different molecular subgroups of GISTs. This review summarizes all the current evidences supporting the key role of the FGF/FGFR pathway activation in GISTs, whereby either activating mutations, oncogenic gene fusions, or autocrine/paracrine signaling have been detected in quadruple WT, SDH-deficient, or KIT-mutant GISTs." @default.
- W3023340384 created "2020-05-13" @default.
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- W3023340384 date "2020-05-07" @default.
- W3023340384 modified "2023-09-27" @default.
- W3023340384 title "The Emerging Role of the FGF/FGFR Pathway in Gastrointestinal Stromal Tumor" @default.
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- W3023340384 doi "https://doi.org/10.3390/ijms21093313" @default.
- W3023340384 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7246647" @default.
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