Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023340503> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3023340503 endingPage "971" @default.
- W3023340503 startingPage "966" @default.
- W3023340503 abstract "Abstract Background Felodipine is a calcium channel blocker used together with metoprolol succinate for treatment of hypertension. Objective Two chromatographic methods were developed for simultaneous determination of felodipine (FEL) and metoprolol succinate (MET), and their major metabolites, dehydrofelodipine and metoprolol acid, respectively. Methods The first method was RP-HPLC which comprised separation of the studied components by gradient elution using a Phenomenex C8 column and a mobile phase composed of water (adjusted to pH 3.5 with o-phosphoric acid)–acetonitrile – methanol (45:40:15, by volume) for the first 6 min and (30:60:10, by volume) for the next 4 min at a flow rate of 1 mL/min followed by UV detection of the eluted peaks at 225 nm. The second method was an HPTLC method where separation was achieved using a mobile phase consisting of toluene–ethyl acetate–methanol–ammonia–formic acid (10:5:2.5:0.3:0.1, by volume) and scanning of the separated bands at 225 nm. Results Validation of the developed methods was done according to ICH guidelines. Successful application of the developed methods was carried out for determination of the studied drugs in human spiked plasma and in Logimax® tablets. Conclusions The developed RP-HPLC and HPTLC methods can be further applied for quality control testing of the studied drugs. Highlights RP-HPLC and HPTLC methods for determination of FEL, MET and their major metabolites. The developed methods were successfully applied for determination of FEL and MET in Logimax® tablets." @default.
- W3023340503 created "2020-05-13" @default.
- W3023340503 creator A5016506506 @default.
- W3023340503 creator A5033683744 @default.
- W3023340503 creator A5074199404 @default.
- W3023340503 creator A5087838298 @default.
- W3023340503 date "2020-05-03" @default.
- W3023340503 modified "2023-09-26" @default.
- W3023340503 title "Development and Validation of RP-HPLC and an Ecofriendly HPTLC Method for Simultaneous Determination of Felodipine and Metoprolol Succinate, and their Major Metabolites in Human Spiked Plasma" @default.
- W3023340503 cites W1964396301 @default.
- W3023340503 cites W1966459373 @default.
- W3023340503 cites W2012707227 @default.
- W3023340503 cites W2031794273 @default.
- W3023340503 cites W2086155907 @default.
- W3023340503 cites W2099491304 @default.
- W3023340503 cites W2152381901 @default.
- W3023340503 cites W2160972816 @default.
- W3023340503 cites W619080474 @default.
- W3023340503 doi "https://doi.org/10.1093/jaoacint/qsz040" @default.
- W3023340503 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33241342" @default.
- W3023340503 hasPublicationYear "2020" @default.
- W3023340503 type Work @default.
- W3023340503 sameAs 3023340503 @default.
- W3023340503 citedByCount "5" @default.
- W3023340503 countsByYear W30233405032022 @default.
- W3023340503 countsByYear W30233405032023 @default.
- W3023340503 crossrefType "journal-article" @default.
- W3023340503 hasAuthorship W3023340503A5016506506 @default.
- W3023340503 hasAuthorship W3023340503A5033683744 @default.
- W3023340503 hasAuthorship W3023340503A5074199404 @default.
- W3023340503 hasAuthorship W3023340503A5087838298 @default.
- W3023340503 hasBestOaLocation W30233405031 @default.
- W3023340503 hasConcept C126838900 @default.
- W3023340503 hasConcept C164705383 @default.
- W3023340503 hasConcept C178790620 @default.
- W3023340503 hasConcept C179998833 @default.
- W3023340503 hasConcept C185592680 @default.
- W3023340503 hasConcept C2776622989 @default.
- W3023340503 hasConcept C2777379063 @default.
- W3023340503 hasConcept C2779607525 @default.
- W3023340503 hasConcept C2780648877 @default.
- W3023340503 hasConcept C2780782300 @default.
- W3023340503 hasConcept C2781280847 @default.
- W3023340503 hasConcept C43617362 @default.
- W3023340503 hasConcept C71924100 @default.
- W3023340503 hasConcept C73826308 @default.
- W3023340503 hasConcept C84393581 @default.
- W3023340503 hasConceptScore W3023340503C126838900 @default.
- W3023340503 hasConceptScore W3023340503C164705383 @default.
- W3023340503 hasConceptScore W3023340503C178790620 @default.
- W3023340503 hasConceptScore W3023340503C179998833 @default.
- W3023340503 hasConceptScore W3023340503C185592680 @default.
- W3023340503 hasConceptScore W3023340503C2776622989 @default.
- W3023340503 hasConceptScore W3023340503C2777379063 @default.
- W3023340503 hasConceptScore W3023340503C2779607525 @default.
- W3023340503 hasConceptScore W3023340503C2780648877 @default.
- W3023340503 hasConceptScore W3023340503C2780782300 @default.
- W3023340503 hasConceptScore W3023340503C2781280847 @default.
- W3023340503 hasConceptScore W3023340503C43617362 @default.
- W3023340503 hasConceptScore W3023340503C71924100 @default.
- W3023340503 hasConceptScore W3023340503C73826308 @default.
- W3023340503 hasConceptScore W3023340503C84393581 @default.
- W3023340503 hasIssue "4" @default.
- W3023340503 hasLocation W30233405031 @default.
- W3023340503 hasOpenAccess W3023340503 @default.
- W3023340503 hasPrimaryLocation W30233405031 @default.
- W3023340503 hasRelatedWork W1028962968 @default.
- W3023340503 hasRelatedWork W2012024754 @default.
- W3023340503 hasRelatedWork W2043512602 @default.
- W3023340503 hasRelatedWork W2077423873 @default.
- W3023340503 hasRelatedWork W2109904578 @default.
- W3023340503 hasRelatedWork W2347336114 @default.
- W3023340503 hasRelatedWork W2354740489 @default.
- W3023340503 hasRelatedWork W2363975049 @default.
- W3023340503 hasRelatedWork W2371499293 @default.
- W3023340503 hasRelatedWork W2385174082 @default.
- W3023340503 hasVolume "103" @default.
- W3023340503 isParatext "false" @default.
- W3023340503 isRetracted "false" @default.
- W3023340503 magId "3023340503" @default.
- W3023340503 workType "article" @default.