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- W3023343351 abstract "Abstract The ancestors of Cetacea underwent profound morpho-physiological alterations. By displaying an exclusive aquatic existence, cetaceans evolved unique patterns of locomotor activity, vigilant behaviour, thermoregulation and circadian rhythmicity. Deciphering the molecular landscape governing many of these adaptations is key to understand the evolution of phenotypes. Here, we investigate Cortistatin ( CORT ), a neuropeptide displaying an important role mammalian biorhythm regulation. This neuropeptide is a known neuroendocrine factor, stimulating slow-wave sleep, but also involved in the regulation of energy metabolism and hypomotility inducement. We assessed the functional status of CORT in 139 mammalian genomes (25 orders), including 30 species of Cetacea. Our findings indicate that cetaceans and other mammals with atypical biorhythms, thermal constraints and/or energy metabolism, have accumulated deleterious mutations in CORT . In light of the pleiotropic action of this neuropeptide, we suggest that this inactivation contributed to a plethora of phenotypic adjustments to accommodate adaptive solutions to specific ecological niches." @default.
- W3023343351 created "2020-05-13" @default.
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- W3023343351 date "2020-05-12" @default.
- W3023343351 modified "2023-09-28" @default.
- W3023343351 title "Differential Cetacea Circadian Rhythmicity is associated with the molecular erosion of Cortistatin" @default.
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- W3023343351 doi "https://doi.org/10.1101/2020.05.11.087833" @default.
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