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• W3023347637 abstract "Five new lignans, euphorhirtins A-D (1-4), 5-methoxyvirgatusin (5), three artefacts, 7S-ethoxyisolintetralin (6), 7R-ethoxyisolintetralin (7), and 7R-ethoxy-3-methoxyisolintetralin (8), together with 13 known ones (9-21) were isolated from the medicinal plant Euphorbia hirta L. The structures of the compounds were elucidated by means of extensive spectroscopic analysis, including 1D and 2D NMR and HR-ESI-MS experiments. The absolute configurations of compound 1 was determined by ECD calculation. The isolates were evaluated for their inhibitory effects against the proliferation of the cancer cell lines (Hep G2, A549, and DU145) and compounds 14 and 18 showed inhibitory activity against the Hep G2 cells with IC50 values 7.2 ± 0.17 and 8.5 ± 0.36 μM." @default.
• W3023347637 created "2020-05-13" @default.
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• W3023347637 date "2020-05-06" @default.
• W3023347637 modified "2023-09-22" @default.
• W3023347637 title "Lignans from <i>Euphorbia hirta</i> L." @default.
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• W3023347637 doi "https://doi.org/10.1080/14786419.2020.1761358" @default.
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