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- W3023373398 abstract "To determine the influence of concomitant radiochemotherapy with cisplatin on parotid gland tissue complication probability. Patients treated either with radiotherapy (n = 61) or concomitant radiochemotherapy with cisplatin (n = 36) for head and neck cancer were prospectively evaluated. The dose and volume distributions of the parotid glands were noted in dose-volume-histograms. Stimulated salivary flow rates were measured before, during the 2nd and 6th week and at 4 weeks and 6 months after the treatment. The data were fit using the normal tissue complication probability (NTCP) model of Lyman. Complication was defined as a reduction of the salivary flow rate to < 25% of the pre-treatment flow rate. The NTCP-model parameter TD50 (the dose leading to a complication probability of 50%) was found to be 32.2 Gy at 4 weeks and 32.1 Gy at 6 months for concomitant radiochemotherapy and 41.1 Gy at 4 weeks and 39.6 Gy at 6 months for radiotherapy. The tolerated dose for concomitant radiochemotherapy was at least 7 – 8 Gy lower than for radiotherapy alone at TD50. In this study, the concomitant radiochemotherapy tends to cause a higher probability of parotid gland tissue damage. Advanced radiotherapy planning approaches such as IMRT may be particularly important for parotid sparing in radiochemotherapy due to cisplatin-related increased radiosensitivity of glands." @default.
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- W3023373398 date "2009-11-01" @default.
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- W3023373398 title "Effect of Cisplatin on Parotid Gland Function in Concomitant Radiochemotherapy" @default.
- W3023373398 doi "https://doi.org/10.1016/j.ijrobp.2009.07.896" @default.
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