FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023404482> ?p ?o ?g. }

• W3023404482 abstract "Paracetamol has been commonly used for the relief of postoperative pain following oral surgery. In this review we investigated the optimal dose of paracetamol and the optimal time for drug administration to provide pain relief, taking into account the side effects of different doses of the drug. This will inform dentists and their patients of the best strategy for pain relief after the surgical removal of wisdom teeth.To assess the beneficial and harmful effects of paracetamol for pain relief after surgical removal of lower wisdom teeth, compared to placebo, at different doses and administered postoperatively.We searched the Cochrane Oral Health Group's Trials Register; the Cochrane Pain, Palliative and Supportive Care Group's Trials Register; CENTRAL; MEDLINE; EMBASE and the Current Controlled Trials Register. Handsearching included several dental journals. We checked the bibliographies of relevant clinical trials and review articles for studies outside the handsearched journals. We wrote to authors of the identified randomised controlled trials (RCTs), to manufacturers of analgesic pharmaceuticals, we searched personal references in an attempt to identify unpublished or ongoing RCTs. No language restriction was applied. The last electronic search was conducted on 24th August 2006.Randomised, parallel group, placebo controlled, double blind clinical trials of paracetamol for acute pain, following third molar surgery.All trials identified were scanned independently and in duplicate by two review authors, any disagreements were resolved by discussion, or if necessary a third review author was consulted. The proportion of patients with at least 50% pain relief was calculated for both paracetamol and placebo. The number of patients experiencing adverse events, and/or the total number of adverse events reported were analysed.Twenty-one trials met the inclusion criteria. A total of 2048 patients were initially enrolled in the trials (1148 received paracetamol, and 892 the placebo) and of these 1968 (96%) were included in the meta-analysis (1133 received paracetamol, and 835 the placebo). Paracetamol provided a statistically significant benefit when compared with placebo for pain relief and pain intensity at both 4 and 6 hours. Most studies were found to have moderate risk of bias, with poorly reported allocation concealment being the main problem. Risk ratio values for pain relief at 4 hours 2.85 (95% confidence interval (CI) 1.89 to 4.29), and at 6 hours 3.32 (95% CI 1.88 to 5.87). A statistically significant benefit was also found between up to 1000 mg and 1000 mg doses, the higher the dose giving greater benefit for each measure at both time points. There was no statistically significant difference between the number of patients who reported adverse events, overall this being 19% in the paracetamol group and 16% in the placebo group.Paracetamol is a safe, effective drug for the treatment of postoperative pain following the surgical removal of lower wisdom teeth." @default.
• W3023404482 created "2020-05-13" @default.
• W3023404482 creator A5007103570 @default.
• W3023404482 creator A5040576917 @default.
• W3023404482 creator A5049156444 @default.
• W3023404482 creator A5067775878 @default.
• W3023404482 creator A5075097700 @default.
• W3023404482 creator A5083667344 @default.
• W3023404482 creator A5084110862 @default.
• W3023404482 date "2007-07-18" @default.
• W3023404482 modified "2023-10-18" @default.
• W3023404482 title "Paracetamol for pain relief after surgical removal of lower wisdom teeth" @default.
• W3023404482 cites W1504991804 @default.
• W3023404482 cites W1511030866 @default.
• W3023404482 cites W1539310683 @default.
• W3023404482 cites W154577255 @default.
• W3023404482 cites W1570746906 @default.
• W3023404482 cites W160421360 @default.
• W3023404482 cites W168743389 @default.
• W3023404482 cites W184535809 @default.
• W3023404482 cites W1880108824 @default.
• W3023404482 cites W188514626 @default.
• W3023404482 cites W18990399 @default.
• W3023404482 cites W1921015236 @default.
• W3023404482 cites W1922654657 @default.
• W3023404482 cites W193793720 @default.
• W3023404482 cites W1948716080 @default.
• W3023404482 cites W1967190610 @default.
• W3023404482 cites W1969130729 @default.
• W3023404482 cites W1970045841 @default.
• W3023404482 cites W1972399518 @default.
• W3023404482 cites W1974250647 @default.
• W3023404482 cites W1979867611 @default.
• W3023404482 cites W1983842309 @default.
• W3023404482 cites W1984159156 @default.
• W3023404482 cites W1991139506 @default.
• W3023404482 cites W1998238709 @default.
• W3023404482 cites W2000165870 @default.
• W3023404482 cites W2000361523 @default.
• W3023404482 cites W2000428767 @default.
• W3023404482 cites W2003125974 @default.
• W3023404482 cites W2006151192 @default.
• W3023404482 cites W2013126040 @default.
• W3023404482 cites W2014705084 @default.
• W3023404482 cites W2018051976 @default.
• W3023404482 cites W2022129350 @default.
• W3023404482 cites W2023452855 @default.
• W3023404482 cites W2024289681 @default.
• W3023404482 cites W2025154517 @default.
• W3023404482 cites W2026682659 @default.
• W3023404482 cites W2031997610 @default.
• W3023404482 cites W2037382867 @default.
• W3023404482 cites W2039674859 @default.
• W3023404482 cites W2040274511 @default.
• W3023404482 cites W2042283784 @default.
• W3023404482 cites W2049048114 @default.
• W3023404482 cites W2050876376 @default.
• W3023404482 cites W2051552289 @default.
• W3023404482 cites W2053500544 @default.
• W3023404482 cites W2057697168 @default.
• W3023404482 cites W2071486280 @default.
• W3023404482 cites W2072882657 @default.
• W3023404482 cites W2078505343 @default.
• W3023404482 cites W2079776252 @default.
• W3023404482 cites W2093118515 @default.
• W3023404482 cites W2104218808 @default.
• W3023404482 cites W2104700251 @default.
• W3023404482 cites W2121557943 @default.
• W3023404482 cites W2149045874 @default.
• W3023404482 cites W2159017711 @default.
• W3023404482 cites W2159173512 @default.
• W3023404482 cites W2164464321 @default.
• W3023404482 cites W2235570983 @default.
• W3023404482 cites W2308896283 @default.
• W3023404482 cites W2322720491 @default.
• W3023404482 cites W2398163818 @default.
• W3023404482 cites W2402950044 @default.
• W3023404482 cites W2407668297 @default.
• W3023404482 cites W2409568957 @default.
• W3023404482 cites W2409852832 @default.
• W3023404482 cites W2410165868 @default.
• W3023404482 cites W2416075064 @default.
• W3023404482 cites W2417760322 @default.
• W3023404482 cites W2431245822 @default.
• W3023404482 cites W2431255623 @default.
• W3023404482 cites W2436303609 @default.
• W3023404482 cites W3147706700 @default.
• W3023404482 cites W4213054763 @default.
• W3023404482 cites W4243574642 @default.
• W3023404482 doi "https://doi.org/10.1002/14651858.cd004487.pub2" @default.
• W3023404482 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7388061" @default.
• W3023404482 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17636762" @default.
• W3023404482 hasPublicationYear "2007" @default.
• W3023404482 type Work @default.
• W3023404482 sameAs 3023404482 @default.
• W3023404482 citedByCount "48" @default.
• W3023404482 countsByYear W30234044822012 @default.
• W3023404482 countsByYear W30234044822013 @default.
• W3023404482 countsByYear W30234044822014 @default.
• W3023404482 countsByYear W30234044822015 @default.

• next