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- W3023405770 abstract "As Alzheimer's disease (AD) progresses many sufferers experience additional behavioral and psychological symptoms such as psychosis. Psychotic symptoms are reported to affect 40–60% of individuals with AD and are associated with more rapid cognitive and functional decline, more severe cognitive impairment, premature institutionalization, and increased risks for agitated and aggressive behavior. Several studies demonstrate excess aggregation of psychosis in families, suggesting that psychosis in Alzheimer's disease (AD+P) represents a distinct subtype that is, in part, genetically determined. Recent studies in schizophrenia, bipolar affective disorder (BPAD) and AD+P suggest that psychosis susceptibility or modifier genes may act across the “disease divide”. Support for this hypothesis includes the results of multiple linkage studies, which indicate that a gene or genes influencing AD+P, schizophrenia and BPAD may reside within the same or proximal chromosomal regions. To investigate putative functional candidate genes in regions implicated by our AD+P linkage screen. To study susceptibility markers for psychosis related disorders in AD and AD+P. Polymorphisms were chosen on the basis of location in putative functional and positional candidate genes. Well defined susceptibility markers and haplotypes for schizophrenia, BPAD with psychosis and Huntingdon's disease (HD) with psychosis were also studied. Polymorphisms from four genes (GRIK2, COMT, NRG1 and DTNBP1) were individually genotyped in a large AD sample (1205 Caucasian UK patients; 1361 controls matched for age, sex and ethnicity). Initial results show little association of the chosen polymorphisms with AD or AD+P. The GRIK2 SNP rs6922753 showed significant association with BPAD in two independent samples (combined p=0.00033). Analysis of rs6922753 in the AD sample (968 cases and 1142 controls) showed that there were no differences in either genotype (p=0.55) or allele frequency (p=0.31). Stratification for gender (664 female patients; allelic p=0.39: 274 male patients; allelic p=0.50) and AD+P (n=340; p=0.968) also showed no significant association." @default.
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- W3023405770 date "2006-07-01" @default.
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- W3023405770 title "P1-327: Testing for association between Alzheimer's disease with psychosis and functional gene candidates" @default.
- W3023405770 doi "https://doi.org/10.1016/j.jalz.2006.05.705" @default.
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