Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023410166> ?p ?o ?g. }
- W3023410166 abstract "Different subsets of the tRNA pool in human are expressed in different cellular conditions. The 'proliferation-tRNAs' are induced upon normal and cancerous cell division, while the 'differentiation tRNAs' are active in non-dividing, differentiated cells. Here we examine the essentiality of the various tRNAs upon cellular growth and arrest. We established a CRISPR-based editing procedure with sgRNAs that each target a tRNA family. We measured tRNA essentiality for cellular growth and found that most proliferation tRNAs are essential compared to differentiation tRNAs in rapidly growing cell lines. Yet in more slowly dividing lines, the differentiation tRNAs were more essential. In addition, we measured these tRNAs roles upon response to cell cycle arresting signals. Here we detected a more complex behavior with both proliferation-tRNAs and differentiation tRNAs showing various levels of essentiality. These results provide the so-far most comprehensive functional characterization of human tRNAs with intricate roles in various proliferation states." @default.
- W3023410166 created "2020-05-13" @default.
- W3023410166 creator A5001688398 @default.
- W3023410166 creator A5005581639 @default.
- W3023410166 creator A5020266319 @default.
- W3023410166 creator A5029315819 @default.
- W3023410166 creator A5040057015 @default.
- W3023410166 creator A5050900886 @default.
- W3023410166 date "2020-05-02" @default.
- W3023410166 modified "2023-09-24" @default.
- W3023410166 title "Manipulation of the human tRNA pool reveals distinct tRNA sets that act in cellular proliferation or cell cycle arrest" @default.
- W3023410166 cites W1644764835 @default.
- W3023410166 cites W1963704214 @default.
- W3023410166 cites W1970472050 @default.
- W3023410166 cites W1996769980 @default.
- W3023410166 cites W2006986876 @default.
- W3023410166 cites W2009668465 @default.
- W3023410166 cites W2009709163 @default.
- W3023410166 cites W2013321787 @default.
- W3023410166 cites W2021200503 @default.
- W3023410166 cites W2026004604 @default.
- W3023410166 cites W2040694119 @default.
- W3023410166 cites W2049424828 @default.
- W3023410166 cites W2055639102 @default.
- W3023410166 cites W2060593129 @default.
- W3023410166 cites W2065782380 @default.
- W3023410166 cites W2075670261 @default.
- W3023410166 cites W2087999409 @default.
- W3023410166 cites W2091015937 @default.
- W3023410166 cites W2102225814 @default.
- W3023410166 cites W2107804881 @default.
- W3023410166 cites W2112243735 @default.
- W3023410166 cites W2114147818 @default.
- W3023410166 cites W2117692326 @default.
- W3023410166 cites W2124711114 @default.
- W3023410166 cites W2153028195 @default.
- W3023410166 cites W2154608547 @default.
- W3023410166 cites W2155765704 @default.
- W3023410166 cites W2157205823 @default.
- W3023410166 cites W2162170988 @default.
- W3023410166 cites W2162262059 @default.
- W3023410166 cites W2162598202 @default.
- W3023410166 cites W2167171238 @default.
- W3023410166 cites W2171813323 @default.
- W3023410166 cites W2209651181 @default.
- W3023410166 cites W2300220838 @default.
- W3023410166 cites W2393535458 @default.
- W3023410166 cites W2418276263 @default.
- W3023410166 cites W2470801200 @default.
- W3023410166 cites W2511683759 @default.
- W3023410166 cites W2607137613 @default.
- W3023410166 cites W2747878742 @default.
- W3023410166 cites W2749511637 @default.
- W3023410166 cites W2760582164 @default.
- W3023410166 cites W2762868004 @default.
- W3023410166 cites W2792897553 @default.
- W3023410166 cites W2803275252 @default.
- W3023410166 cites W2808878318 @default.
- W3023410166 cites W2888496837 @default.
- W3023410166 cites W2904828830 @default.
- W3023410166 cites W2920207301 @default.
- W3023410166 cites W2949766441 @default.
- W3023410166 cites W2950649988 @default.
- W3023410166 cites W2954376097 @default.
- W3023410166 cites W2978981832 @default.
- W3023410166 cites W3010107238 @default.
- W3023410166 cites W3013024503 @default.
- W3023410166 cites W3014935338 @default.
- W3023410166 doi "https://doi.org/10.1101/2020.04.30.070789" @default.
- W3023410166 hasPublicationYear "2020" @default.
- W3023410166 type Work @default.
- W3023410166 sameAs 3023410166 @default.
- W3023410166 citedByCount "1" @default.
- W3023410166 countsByYear W30234101662020 @default.
- W3023410166 crossrefType "posted-content" @default.
- W3023410166 hasAuthorship W3023410166A5001688398 @default.
- W3023410166 hasAuthorship W3023410166A5005581639 @default.
- W3023410166 hasAuthorship W3023410166A5020266319 @default.
- W3023410166 hasAuthorship W3023410166A5029315819 @default.
- W3023410166 hasAuthorship W3023410166A5040057015 @default.
- W3023410166 hasAuthorship W3023410166A5050900886 @default.
- W3023410166 hasBestOaLocation W30234101661 @default.
- W3023410166 hasConcept C104317684 @default.
- W3023410166 hasConcept C105580179 @default.
- W3023410166 hasConcept C148738053 @default.
- W3023410166 hasConcept C1491633281 @default.
- W3023410166 hasConcept C149364088 @default.
- W3023410166 hasConcept C153957851 @default.
- W3023410166 hasConcept C29537977 @default.
- W3023410166 hasConcept C54355233 @default.
- W3023410166 hasConcept C62112901 @default.
- W3023410166 hasConcept C67705224 @default.
- W3023410166 hasConcept C85813293 @default.
- W3023410166 hasConcept C86803240 @default.
- W3023410166 hasConcept C95444343 @default.
- W3023410166 hasConceptScore W3023410166C104317684 @default.
- W3023410166 hasConceptScore W3023410166C105580179 @default.
- W3023410166 hasConceptScore W3023410166C148738053 @default.
- W3023410166 hasConceptScore W3023410166C1491633281 @default.
- W3023410166 hasConceptScore W3023410166C149364088 @default.