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• W3023434211 abstract "The delivery of antineoplastic agents directly into the peritoneal cavity as treatment of malignancies principally confined to this body compartment (e.g., ovarian cancer) is based on sound pharmacokinetic and anatomic principles. Over the past two decades investigators have defined both the potential benefits, and limitations, associated with this unique method of drug delivery in the treatment of ovarian cancer. Recently, two large well-designed and conducted randomized phase III trials have confirmed a survival advantage associated with the administration of cisplatin by the intraperitoneal route in the initial treatment of advanced small volume residual advanced ovarian cancer, compared to the systemic delivery of the same cytotoxic drug. In several clinical settings involving patients with ovarian cancer, fallopian tube cancer, or primary peritoneal carcinoma it is appropriate to consider intraperitoneal treatment (generally with either cisplatin or carboplatin) as a rationale management option. These include: (1) patients who achieve a major response following therapy with systemic platinum-based treatment, but who persist in having microscopic or very small volume residual macroscopic disease (largest tumor nodule < 0.5–1 cm in maximal diameter) at the time of a secondlook laparotomy/laparoscopy; (2) patients with large volume intraperitoneal disease, or those with grade 3 tumors, who achieve a surgically-documented complete response following systemic chemotherapy (“consolidation therapy”); and (3) previously untreated patients with stage 3A (microscopic disease only in the upper abdomen) or those with stages 3B or 3C disease who have no visible macroscopic cancer following initial surgical cytoreduction." @default.
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• W3023434211 date "2003-01-01" @default.
• W3023434211 modified "2023-09-27" @default.
• W3023434211 title "Intraperitoneal Chemotherapy" @default.
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