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• W3023438549 endingPage "124" @default.
• W3023438549 startingPage "116" @default.
• W3023438549 abstract "Emphysema is one of the main manifestations of chronic obstructive pulmonary disease (COPD), and smoking is one of the most significant risk factors. The results of studies in humans and animals show the vascular endothelium initiates and modulates the main pathological processes in COPD and smoking is an important factor initiating, developing and persisting inflammation and remodeling of blood vessels and tissues, including the destruction of small respiratory tracts with the development of lung tissue destruction and emphysema. The latest studies describe mechanisms not just associated with the endothelium, but specific neuro-mediated mechanisms. There is reason to believe that neuro-mediated and neuro-similar mechanisms associated and not related to endothelial dysfunction may play the significant role in the pathogenesis of COPD and emphysema formation. Information about components and mechanisms of neurogenic inflammation in emphysema development is fragmentary and not systematized in the literature. It is described that long-term tobacco smoking can initiate processes not only of cells and tissues damage, but also become a trigger for excessive release of neurotransmitters, which entails whole cascades of adverse reactions that have an effect on emphysema formation. With prolonged and/or intensive stimulation of sensor fibers, excessive release of neuropeptides is accompanied by a number of plastic and destructive processes due to a cascade of pathological reactions of neurogenic inflammation, the main participants of which are classical neuropeptides and their receptors. The most important consequences can be the maintenance and stagnation of chronic inflammation, activation of the mechanisms of destruction and remodeling, inadequate repair processes in response to damage, resulting in irreversible loss of lung tissue. For future research, there is interest to evaluate the possibilities of therapeutic and prophylactic effects on neuro-mediated mechanisms of endothelial dysfunction and damage emphysema in COPD and smoking development." @default.
• W3023438549 created "2020-05-13" @default.
• W3023438549 creator A5017128811 @default.
• W3023438549 creator A5019357082 @default.
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• W3023438549 creator A5090240906 @default.
• W3023438549 date "2020-03-27" @default.
• W3023438549 modified "2023-10-18" @default.
• W3023438549 title "Endothelium-related and neuro-mediated mechanisms of emphysema development in chronic obstructive pulmonary disease" @default.
• W3023438549 cites W1480191525 @default.
• W3023438549 cites W1574273384 @default.
• W3023438549 cites W1963754681 @default.
• W3023438549 cites W1966999276 @default.
• W3023438549 cites W1976881101 @default.
• W3023438549 cites W1978733496 @default.
• W3023438549 cites W1982945932 @default.
• W3023438549 cites W1992940048 @default.
• W3023438549 cites W2000053335 @default.
• W3023438549 cites W2000312799 @default.
• W3023438549 cites W2005614498 @default.
• W3023438549 cites W2024960729 @default.
• W3023438549 cites W2036290805 @default.
• W3023438549 cites W2049445148 @default.
• W3023438549 cites W2057586331 @default.
• W3023438549 cites W2060937153 @default.
• W3023438549 cites W2071599436 @default.
• W3023438549 cites W2073840833 @default.
• W3023438549 cites W2078948823 @default.
• W3023438549 cites W2082022222 @default.
• W3023438549 cites W2087404728 @default.
• W3023438549 cites W2090134402 @default.
• W3023438549 cites W2103750504 @default.
• W3023438549 cites W2106656741 @default.
• W3023438549 cites W2112131371 @default.
• W3023438549 cites W2114258740 @default.
• W3023438549 cites W2115860058 @default.
• W3023438549 cites W2120833879 @default.
• W3023438549 cites W2121001275 @default.
• W3023438549 cites W2121036731 @default.
• W3023438549 cites W2124631075 @default.
• W3023438549 cites W2127131462 @default.
• W3023438549 cites W2134480887 @default.
• W3023438549 cites W2136327958 @default.
• W3023438549 cites W2140412940 @default.
• W3023438549 cites W2140463692 @default.
• W3023438549 cites W2140647939 @default.
• W3023438549 cites W2143763541 @default.
• W3023438549 cites W2145661651 @default.
• W3023438549 cites W2149026439 @default.
• W3023438549 cites W2149432618 @default.
• W3023438549 cites W2150839127 @default.
• W3023438549 cites W2161165188 @default.
• W3023438549 cites W2162313549 @default.
• W3023438549 cites W2163274209 @default.
• W3023438549 cites W2164999687 @default.
• W3023438549 cites W2165115219 @default.
• W3023438549 cites W2166983069 @default.
• W3023438549 cites W2170476507 @default.
• W3023438549 cites W2173756899 @default.
• W3023438549 cites W2175357599 @default.
• W3023438549 cites W2224385815 @default.
• W3023438549 cites W2319054105 @default.
• W3023438549 cites W2333720890 @default.
• W3023438549 cites W2334275131 @default.
• W3023438549 cites W2338929961 @default.
• W3023438549 cites W2366256932 @default.
• W3023438549 cites W2577729502 @default.
• W3023438549 cites W2579847452 @default.
• W3023438549 cites W2585486857 @default.
• W3023438549 cites W2620611580 @default.
• W3023438549 cites W2698307513 @default.
• W3023438549 cites W2736179926 @default.
• W3023438549 cites W2736382892 @default.
• W3023438549 cites W2750749196 @default.
• W3023438549 cites W2781752762 @default.
• W3023438549 cites W2781887955 @default.
• W3023438549 cites W2783827486 @default.
• W3023438549 cites W2784297905 @default.
• W3023438549 cites W2788469663 @default.
• W3023438549 cites W2788883450 @default.
• W3023438549 cites W2790265910 @default.
• W3023438549 cites W2792158386 @default.
• W3023438549 cites W2793849010 @default.
• W3023438549 cites W2794691708 @default.
• W3023438549 cites W2800454404 @default.
• W3023438549 cites W2802900098 @default.
• W3023438549 cites W2885968272 @default.
• W3023438549 cites W2897163872 @default.
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• W3023438549 doi "https://doi.org/10.26442/00403660.2020.03.000347" @default.
• W3023438549 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32598803" @default.
• W3023438549 hasPublicationYear "2020" @default.
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