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• W3023444200 abstract "This chapter discusses the role of Ca2+-ATPases in maintaining Ca2+ homeostasis in the cell. The chapter focuses on sarcoplasmic reticular (SR) Ca2+-ATPase(s), which is the primary regulator of the Ca2+ levels and thus, contractility in muscle. Ca2+ is a physiological regulator for the contractile proteins and several other enzymes and processes in muscle. The chapter discusses sarcoplasmic reticular (SR) Ca2+ -ATPase, and several other ATPases. Sarcoplasmic reticular (SR) Ca2+ includes properties of SR Ca2+ -ATPase, regulation of SR Ca2+-ATPase by phospholamban, and SR Ca2+ -ATPase in cardiac diseases. Regulation of SR Ca2+-ATPase by phospholamban further includes, structure of phospholamban, in vitro studies on regulation of SR Ca2+-ATPase, in vivo studies on regulation of SR Ca2+-ATPase. SR Ca2+ -ATPase in cardiac diseases includes SR Ca2+-ATPase in hyperthyroidism and hypothyroidism, SR Ca2+-ATPase in cardiomyopathies, and SR Ca2+-ATPase in ischemia. The SR in both skeletal and cardiac muscles contains an acidic protein, calsequestrin, which binds 40–50 mol of Ca2+ per mol of protein. In cardiac muscle, slow-twitch skeletal muscle, and smooth muscle, the SR contains the low-molecular-weight protein phospholamban, which can be phosphorylated by various protein kinases. Phosphorylation of phospholamban occurs by cAMP dependent, cGMP-dependent, Ca2+-calmodulin-dependent, and Ca2+-phospholipid-dependent protein kinases in vitro. The complex regulation of the SR function clearly indicates that even small disturbances in SR Ca2+ handling may result in profound changes and deterioration of normal myocardial function. Thyroid hormones are important regulators of myocardial contractility and relaxation.. The general properties and structure of plasma membrane Ca2+-ATPase(s) are portrayed in detail. It is mentioned that there is a growing interest in further use of molecular biological approaches and specifically site directed mutagenesis for these enzymes to obtain more information about their structural-functional relationships." @default.
• W3023444200 created "2020-05-13" @default.
• W3023444200 creator A5060727278 @default.
• W3023444200 creator A5080329479 @default.
• W3023444200 date "2001-01-01" @default.
• W3023444200 modified "2023-10-16" @default.
• W3023444200 title "Ca2+-ATPases" @default.
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• W3023444200 doi "https://doi.org/10.1016/b978-012656976-6/50110-4" @default.
• W3023444200 hasPublicationYear "2001" @default.
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