Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023450980> ?p ?o ?g. }
- W3023450980 endingPage "123" @default.
- W3023450980 startingPage "59" @default.
- W3023450980 abstract "Publisher SummaryThis chapter presents a discussion on chemical neurotransmission and role of chemical neurotransmitters in the prefrontal cortex. It begins with an introduction to neurotransmitters and neurotransmitter receptors. Cells produce certain chemical substances called neurotransmitters and neuromodulators that, through specific receptors embedded in pre- and postsynaptic membranes, modify the electrical activity of other nerve cells. The most important classes of neurotransmitters thus far identified in the cerebral cortex include: amino acids (i.e. glutamate (Glu), aspartate, γ -aminobutyric acid [GABA]); the monoamines, including two catecholamines, dopamine (DA) and norepinephrine (NE), and an indoleamine, 5-hydroxytriptamine (5-HT) or serotonin; Acetylcholine (ACh); and neuropeptides (e.g., enkephalins, substance P, somatostatin, neurotensin). Among the six best-known transmitters in prefrontal transmitters include Glu, GABA, NE, DA, 5-HT, and Ach. GABA is the prime inhibitory neurotransmitter in the central nervous system. Glutamate is the prime excitatory neurotransmitter in the cortex. It serves not only the local prefrontal circuitry but also the excitatory connectivity of the prefrontal cortex with striatal, thalamic, and limbic structures. The three monoaminergic systems, with their cells of origin in the brainstem, innervate the prefrontal cortex by way of ascending fiber paths that bypass the thalamus: the noradrenergic system (its transmitter NE) from the nucleus coeruleus, the dopaminergic system (its transmitter DA) from the ventral tegmentum, and the serotonergic system (its transmitter, serotonin, 5-HT) from the nuclei of the raphe. In addition to the monoamines, the prefrontal cortex, like the rest of the neocortex, receives profuse afferents from the subcortical components of the cholinergic system. Also active in the prefrontal cortex are a number of neuropeptides (somatostatin, substance P, CCK, angiotensin, neurotensin, and others) that act there as neurotransmitters or neuromodulators." @default.
- W3023450980 created "2020-05-13" @default.
- W3023450980 creator A5062209758 @default.
- W3023450980 date "2008-01-01" @default.
- W3023450980 modified "2023-09-29" @default.
- W3023450980 title "Chemical Neurotransmission" @default.
- W3023450980 cites W1488942925 @default.
- W3023450980 cites W1490354356 @default.
- W3023450980 cites W1496092682 @default.
- W3023450980 cites W1516755758 @default.
- W3023450980 cites W1518696936 @default.
- W3023450980 cites W1520488892 @default.
- W3023450980 cites W1522335173 @default.
- W3023450980 cites W1522956191 @default.
- W3023450980 cites W1541410122 @default.
- W3023450980 cites W1543276710 @default.
- W3023450980 cites W1545336881 @default.
- W3023450980 cites W1557303332 @default.
- W3023450980 cites W1567533370 @default.
- W3023450980 cites W1589353809 @default.
- W3023450980 cites W1597470737 @default.
- W3023450980 cites W1635746382 @default.
- W3023450980 cites W1642699591 @default.
- W3023450980 cites W1654467375 @default.
- W3023450980 cites W1759162153 @default.
- W3023450980 cites W1775539225 @default.
- W3023450980 cites W1783253784 @default.
- W3023450980 cites W1836312020 @default.
- W3023450980 cites W1870077474 @default.
- W3023450980 cites W1884206649 @default.
- W3023450980 cites W1889428062 @default.
- W3023450980 cites W1892194563 @default.
- W3023450980 cites W1896344011 @default.
- W3023450980 cites W1918538946 @default.
- W3023450980 cites W1938381539 @default.
- W3023450980 cites W1939037149 @default.
- W3023450980 cites W1963917463 @default.
- W3023450980 cites W1964174855 @default.
- W3023450980 cites W1964206422 @default.
- W3023450980 cites W1964386076 @default.
- W3023450980 cites W1964698997 @default.
- W3023450980 cites W1964729801 @default.
- W3023450980 cites W1965392517 @default.
- W3023450980 cites W1965756220 @default.
- W3023450980 cites W1965958752 @default.
- W3023450980 cites W1966377499 @default.
- W3023450980 cites W1967292256 @default.
- W3023450980 cites W1967443916 @default.
- W3023450980 cites W1967694983 @default.
- W3023450980 cites W1967770724 @default.
- W3023450980 cites W1968555237 @default.
- W3023450980 cites W1968833042 @default.
- W3023450980 cites W1968884015 @default.
- W3023450980 cites W1969179247 @default.
- W3023450980 cites W1969590010 @default.
- W3023450980 cites W1969844039 @default.
- W3023450980 cites W1970044298 @default.
- W3023450980 cites W1970116189 @default.
- W3023450980 cites W1970342966 @default.
- W3023450980 cites W1970726732 @default.
- W3023450980 cites W1970896862 @default.
- W3023450980 cites W1971162866 @default.
- W3023450980 cites W1972927648 @default.
- W3023450980 cites W1972956970 @default.
- W3023450980 cites W1973042782 @default.
- W3023450980 cites W1973151471 @default.
- W3023450980 cites W1973371295 @default.
- W3023450980 cites W1973406239 @default.
- W3023450980 cites W1974391609 @default.
- W3023450980 cites W1975131753 @default.
- W3023450980 cites W1976229306 @default.
- W3023450980 cites W1976240494 @default.
- W3023450980 cites W1976511025 @default.
- W3023450980 cites W1976782467 @default.
- W3023450980 cites W1977138162 @default.
- W3023450980 cites W1977964638 @default.
- W3023450980 cites W1978598728 @default.
- W3023450980 cites W1979179687 @default.
- W3023450980 cites W1980493703 @default.
- W3023450980 cites W1980555963 @default.
- W3023450980 cites W1980839482 @default.
- W3023450980 cites W1981037418 @default.
- W3023450980 cites W1981102082 @default.
- W3023450980 cites W1981727048 @default.
- W3023450980 cites W1981978150 @default.
- W3023450980 cites W1982104296 @default.
- W3023450980 cites W1982201683 @default.
- W3023450980 cites W1983479721 @default.
- W3023450980 cites W1985363856 @default.
- W3023450980 cites W1985431179 @default.
- W3023450980 cites W1986661319 @default.
- W3023450980 cites W1987419790 @default.
- W3023450980 cites W1988470872 @default.
- W3023450980 cites W1988619576 @default.
- W3023450980 cites W1989606507 @default.
- W3023450980 cites W1989666477 @default.
- W3023450980 cites W1990218919 @default.
- W3023450980 cites W1990552459 @default.