Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023505639> ?p ?o ?g. }
- W3023505639 abstract "ABSTRACT Disease-specific plasma cells (PCs) reactive with transglutaminase 2 (TG2) or deamidated gluten peptides (DGP) are abundant in celiac disease (CeD) gut lesions. Their contribution toward CeD pathogenesis is unclear. We assessed expression of markers associated with PC longevity in 15 untreated and 26 treated CeD patients in addition to 13 non-CeD controls, and performed RNA-sequencing with clonal inference and transcriptomic analysis of 3251 single PCs. We observed antigen-dependent V-gene selection and stereotypic antibodies. Generation of recombinant DGP-specific antibodies revealed a key role of a heavy-chain residue that displays polymorphism, suggesting that immunoglobulin gene polymorphisms may influence CeD-specific antibody responses. We identified transcriptional differences between CeD-specific vs non-disease-specific PCs and between short-lived vs long-lived PCs. The short-lived CD19 + CD45 + phenotype dominated in untreated and short-term-treated CeD, in particular among disease-specific PCs but also in the general PC population. Thus, the disease lesion of untreated CeD is characterized by massive accumulation of short-lived PCs that are not only directed against disease-specific antigens." @default.
- W3023505639 created "2020-05-13" @default.
- W3023505639 creator A5008586750 @default.
- W3023505639 creator A5012104405 @default.
- W3023505639 creator A5013345893 @default.
- W3023505639 creator A5034188006 @default.
- W3023505639 creator A5047497779 @default.
- W3023505639 creator A5048173015 @default.
- W3023505639 creator A5055685718 @default.
- W3023505639 creator A5065740551 @default.
- W3023505639 creator A5081876747 @default.
- W3023505639 creator A5087994026 @default.
- W3023505639 date "2020-05-02" @default.
- W3023505639 modified "2023-10-18" @default.
- W3023505639 title "Longevity, clonal relationship and transcriptional program of celiac disease-specific plasma cells" @default.
- W3023505639 cites W129719808 @default.
- W3023505639 cites W1654950871 @default.
- W3023505639 cites W1669289223 @default.
- W3023505639 cites W1787452263 @default.
- W3023505639 cites W1940255384 @default.
- W3023505639 cites W1965092590 @default.
- W3023505639 cites W1984687922 @default.
- W3023505639 cites W1996626942 @default.
- W3023505639 cites W2010653277 @default.
- W3023505639 cites W2014996172 @default.
- W3023505639 cites W2026863186 @default.
- W3023505639 cites W2036798664 @default.
- W3023505639 cites W2042578023 @default.
- W3023505639 cites W2055372618 @default.
- W3023505639 cites W2055458431 @default.
- W3023505639 cites W2068767807 @default.
- W3023505639 cites W2076896931 @default.
- W3023505639 cites W2079379547 @default.
- W3023505639 cites W2080891856 @default.
- W3023505639 cites W2082128938 @default.
- W3023505639 cites W2083719521 @default.
- W3023505639 cites W2093123744 @default.
- W3023505639 cites W2095453119 @default.
- W3023505639 cites W2101375662 @default.
- W3023505639 cites W2106539308 @default.
- W3023505639 cites W2109532971 @default.
- W3023505639 cites W2131017558 @default.
- W3023505639 cites W2148495628 @default.
- W3023505639 cites W2158045551 @default.
- W3023505639 cites W2175702062 @default.
- W3023505639 cites W2189537077 @default.
- W3023505639 cites W2197124664 @default.
- W3023505639 cites W2253330825 @default.
- W3023505639 cites W2295703274 @default.
- W3023505639 cites W2337033889 @default.
- W3023505639 cites W2444692547 @default.
- W3023505639 cites W2486397601 @default.
- W3023505639 cites W2524165963 @default.
- W3023505639 cites W2524376318 @default.
- W3023505639 cites W2559951910 @default.
- W3023505639 cites W256420945 @default.
- W3023505639 cites W2579593095 @default.
- W3023505639 cites W2592811885 @default.
- W3023505639 cites W2605978454 @default.
- W3023505639 cites W2610547910 @default.
- W3023505639 cites W2623523065 @default.
- W3023505639 cites W2749266189 @default.
- W3023505639 cites W2751180356 @default.
- W3023505639 cites W2752421511 @default.
- W3023505639 cites W2763051133 @default.
- W3023505639 cites W2800392236 @default.
- W3023505639 cites W2802179555 @default.
- W3023505639 cites W2883469005 @default.
- W3023505639 cites W2888929746 @default.
- W3023505639 cites W2889326414 @default.
- W3023505639 cites W2905625932 @default.
- W3023505639 cites W2951158909 @default.
- W3023505639 cites W2952252081 @default.
- W3023505639 cites W2955556800 @default.
- W3023505639 cites W2965354016 @default.
- W3023505639 cites W2970028555 @default.
- W3023505639 cites W3016195968 @default.
- W3023505639 cites W770237144 @default.
- W3023505639 doi "https://doi.org/10.1101/2020.04.30.058560" @default.
- W3023505639 hasPublicationYear "2020" @default.
- W3023505639 type Work @default.
- W3023505639 sameAs 3023505639 @default.
- W3023505639 citedByCount "3" @default.
- W3023505639 countsByYear W30235056392020 @default.
- W3023505639 countsByYear W30235056392021 @default.
- W3023505639 crossrefType "posted-content" @default.
- W3023505639 hasAuthorship W3023505639A5008586750 @default.
- W3023505639 hasAuthorship W3023505639A5012104405 @default.
- W3023505639 hasAuthorship W3023505639A5013345893 @default.
- W3023505639 hasAuthorship W3023505639A5034188006 @default.
- W3023505639 hasAuthorship W3023505639A5047497779 @default.
- W3023505639 hasAuthorship W3023505639A5048173015 @default.
- W3023505639 hasAuthorship W3023505639A5055685718 @default.
- W3023505639 hasAuthorship W3023505639A5065740551 @default.
- W3023505639 hasAuthorship W3023505639A5081876747 @default.
- W3023505639 hasAuthorship W3023505639A5087994026 @default.
- W3023505639 hasBestOaLocation W30235056391 @default.
- W3023505639 hasConcept C104317684 @default.
- W3023505639 hasConcept C126322002 @default.
- W3023505639 hasConcept C127716648 @default.