Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023510342> ?p ?o ?g. }
- W3023510342 endingPage "753" @default.
- W3023510342 startingPage "741" @default.
- W3023510342 abstract "During sleep and awake rest, the neocortex generates large-scale slow-wave (SW) activity. Here, we report that the claustrum coordinates neocortical SW generation. We established a transgenic mouse line that enabled the genetic interrogation of a subpopulation of claustral glutamatergic neurons. These neurons received inputs from and sent outputs to widespread neocortical areas. The claustral neuronal firings mostly correlated with cortical SW activity. In vitro optogenetic stimulation of the claustrum induced excitatory postsynaptic responses in most neocortical neurons, but elicited action potentials primarily in inhibitory interneurons. In vivo optogenetic stimulation induced a synchronized down-state featuring prolonged silencing of neural activity in all layers of many cortical areas, followed by a down-to-up state transition. In contrast, genetic ablation of claustral neurons attenuated SW activity in the frontal cortex. These results demonstrate a crucial role of claustral neurons in synchronizing inhibitory interneurons across wide cortical areas for the spatiotemporal coordination of SW activity. The authors establish the claustrum-Cre transgenic mouse line and demonstrate that the claustrum orchestrates cortical slow-wave activity by synchronously driving the inhibitory interneurons in widespread cortical areas." @default.
- W3023510342 created "2020-05-13" @default.
- W3023510342 creator A5003923772 @default.
- W3023510342 creator A5009204351 @default.
- W3023510342 creator A5017514518 @default.
- W3023510342 creator A5034828433 @default.
- W3023510342 creator A5045292942 @default.
- W3023510342 creator A5059664782 @default.
- W3023510342 creator A5066468783 @default.
- W3023510342 creator A5075647445 @default.
- W3023510342 date "2020-05-11" @default.
- W3023510342 modified "2023-10-17" @default.
- W3023510342 title "The claustrum coordinates cortical slow-wave activity" @default.
- W3023510342 cites W1516609261 @default.
- W3023510342 cites W1535834148 @default.
- W3023510342 cites W1536357320 @default.
- W3023510342 cites W1863427091 @default.
- W3023510342 cites W1906859819 @default.
- W3023510342 cites W1965435489 @default.
- W3023510342 cites W1973117088 @default.
- W3023510342 cites W1977647750 @default.
- W3023510342 cites W1978658333 @default.
- W3023510342 cites W1979684874 @default.
- W3023510342 cites W1980429239 @default.
- W3023510342 cites W1994874597 @default.
- W3023510342 cites W1999695968 @default.
- W3023510342 cites W2013522645 @default.
- W3023510342 cites W2017295197 @default.
- W3023510342 cites W2018393962 @default.
- W3023510342 cites W2024446380 @default.
- W3023510342 cites W2028765927 @default.
- W3023510342 cites W2039029351 @default.
- W3023510342 cites W2052525598 @default.
- W3023510342 cites W2056661320 @default.
- W3023510342 cites W2058452561 @default.
- W3023510342 cites W2062450961 @default.
- W3023510342 cites W2074183366 @default.
- W3023510342 cites W2079150153 @default.
- W3023510342 cites W2084121616 @default.
- W3023510342 cites W2088425746 @default.
- W3023510342 cites W2089837563 @default.
- W3023510342 cites W2096519870 @default.
- W3023510342 cites W2097661800 @default.
- W3023510342 cites W2102656701 @default.
- W3023510342 cites W2121148760 @default.
- W3023510342 cites W2121817373 @default.
- W3023510342 cites W2121960517 @default.
- W3023510342 cites W2126148882 @default.
- W3023510342 cites W2130421154 @default.
- W3023510342 cites W2146470133 @default.
- W3023510342 cites W2147595049 @default.
- W3023510342 cites W2159289472 @default.
- W3023510342 cites W2168101731 @default.
- W3023510342 cites W2239878504 @default.
- W3023510342 cites W2320413387 @default.
- W3023510342 cites W2403547050 @default.
- W3023510342 cites W2558096878 @default.
- W3023510342 cites W2616328221 @default.
- W3023510342 cites W2646486909 @default.
- W3023510342 cites W2729250854 @default.
- W3023510342 cites W2734327425 @default.
- W3023510342 cites W2781989649 @default.
- W3023510342 cites W2886763750 @default.
- W3023510342 cites W2886911869 @default.
- W3023510342 cites W2891879612 @default.
- W3023510342 cites W2941584304 @default.
- W3023510342 cites W2951395311 @default.
- W3023510342 cites W2970568021 @default.
- W3023510342 cites W2977737202 @default.
- W3023510342 cites W792393746 @default.
- W3023510342 doi "https://doi.org/10.1038/s41593-020-0625-7" @default.
- W3023510342 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32393895" @default.
- W3023510342 hasPublicationYear "2020" @default.
- W3023510342 type Work @default.
- W3023510342 sameAs 3023510342 @default.
- W3023510342 citedByCount "102" @default.
- W3023510342 countsByYear W30235103422020 @default.
- W3023510342 countsByYear W30235103422021 @default.
- W3023510342 countsByYear W30235103422022 @default.
- W3023510342 countsByYear W30235103422023 @default.
- W3023510342 crossrefType "journal-article" @default.
- W3023510342 hasAuthorship W3023510342A5003923772 @default.
- W3023510342 hasAuthorship W3023510342A5009204351 @default.
- W3023510342 hasAuthorship W3023510342A5017514518 @default.
- W3023510342 hasAuthorship W3023510342A5034828433 @default.
- W3023510342 hasAuthorship W3023510342A5045292942 @default.
- W3023510342 hasAuthorship W3023510342A5059664782 @default.
- W3023510342 hasAuthorship W3023510342A5066468783 @default.
- W3023510342 hasAuthorship W3023510342A5075647445 @default.
- W3023510342 hasBestOaLocation W30235103422 @default.
- W3023510342 hasConcept C112592302 @default.
- W3023510342 hasConcept C169760540 @default.
- W3023510342 hasConcept C17077164 @default.
- W3023510342 hasConcept C2777222312 @default.
- W3023510342 hasConcept C2777348757 @default.
- W3023510342 hasConcept C2779920484 @default.
- W3023510342 hasConcept C2780723820 @default.
- W3023510342 hasConcept C50738837 @default.