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• W3023517117 abstract "Chagas’ disease, which is caused by the protozoan Trypanosoma cruzi affects approximately 18 million people in Latin America and still remains as a public health problem. Chronic infection due to T. cruzi can be reactivated in patients with different immunodeficiency states, including those infected with the Human Immunodeficiency Virus (HIV). Reactivation of chronic Chagas’ disease is more frequent and more severe in AIDS patients in comparison with other immunodeficiency diseases.Generally, reactivation of Chagas’ disease in these patients with advanced HIV infection shows signs of a brain mass lesion or an acute and diffuse meningoencephalitis. Less frequently, this clinical complication can present with an acute myocarditis.The diagnosis of neurological reactivation of Chagas’ disease is based on the neuroimaging findings, the cerebrospinal fluid examination, and, eventually, by the histopathological evaluation of the stereotactic brain biopsies. For these reasons, all HIV patients with focal cerebral mass lesions should be evaluated for specific anti-T. cruzi antibodies and for parasitemia, in seropositive people.Only two drugs are available for the treatment of these patients: the nitroimidazole derivate, benznidazole and the nitrofurantoin, nifurtimox.In this chapter, we will analyze several issues concerning Chagas’ disease in AIDS patients, such as its epidemiology, clinical aspects, diagnostic methods, microbiological and histopathological aspects, treatment, and prophylaxis." @default.
• W3023517117 created "2020-05-13" @default.
• W3023517117 creator A5049769929 @default.
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• W3023517117 date "2017-01-01" @default.
• W3023517117 modified "2023-09-22" @default.
• W3023517117 title "AIDS and Chagas’ disease" @default.
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• W3023517117 doi "https://doi.org/10.1016/b978-0-12-801029-7.00031-9" @default.
• W3023517117 hasPublicationYear "2017" @default.
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