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- W3023538642 abstract "Purpose: We previously demonstrated that bariatric surgery (BS), in morbidly obese inviduals, leads to a short-term significant improvement of endothelial function and coronary microvascular function. In this study we assessed whether BS maintains its beneficial effects at long-term follow up. Methods: We studied 20 morbidly obese patients (age 43±9 years, 12 women) without any evidence of cardiovascular disease, who underwent BS. Peripheral vascular dilator function was assessed by brachial artery diameter changes in response to post-ischemic forearm hyperaemia (FMD). Coronary microvascular function was assessed by measuring coronary blood flow (CBF) velocity response to i.v. adenosine (ADO) and to cold pressor test (CPT) in the left anterior descending coronary artery by transthoracic Doppler echocardiography. Patients were studied before BS, after 3 months from BS and at 4±1.5 years follow up. Results: Patients showed a significant improvement of anthropometric variables from baseline, both after 3 months and at follow up. Compared to baseline, FMD improved significantly at 3 months, and this improvement was observed also at long-term follow-up. Similarly, a significant improvement of CBF response to ADO and to CPT was found both at 3 months and at follow up (Table). Table 1 FMD, flow mediated dilation; CBF, coronary blood flow; ADO, adenosine; CPT, cold pressor test; BMI, body mass index. Conclusions: Our data show that, in morbidly obese patients, BS exerts beneficial and long lasting effects on peripheral endothelial function and on coronary microvascular dilator function, which can significantly contribute to the reduction of cardiovascular risk reported to be associated with this intervention." @default.
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- W3023538642 date "2013-08-02" @default.
- W3023538642 modified "2023-10-03" @default.
- W3023538642 title "Long term effects of bariatric surgery on peripheral endothelial function and on coronary microvascular function" @default.
- W3023538642 doi "https://doi.org/10.1093/eurheartj/eht307.p733" @default.
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