FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023555422> ?p ?o ?g. }

• W3023555422 abstract "Publisher SummaryThis chapter focuses on the photobiological and noncalcemic actions of Vitamin D. When human skin is exposed to sunlight, a photochemical process occurs that is essential for the maintenance of calcium homeostasis and a healthy skeleton. During exposure to sunlight, the ultraviolet B portion of the solar spectrum photolyzes 7-dehydrocholesterol (the precursor cholesterol; provitamin D3) to previtamin D3. Once formed, previtamin D3 undergoes an internal isomerization of its three double bonds to form a more thermodynamically stable, 5,6-cis-triene and is transformed in vitamin D3. 7-Dehydrocholesterol is found principally in the cell membrane and within the membrane, the hydrophobic side chain of 7-dehydrocholesterol is aligned with the hydrophobic chains of the fatty acids and cholesterol, thereby restraining the confirmation of previtamin D3 when it is formed. Thus, when 7-dehydrocholesterol is exposed to sunlight, 7- dehydrocholesterol is photolyzed to the s-cis, s-cis conformer of previtamin D3. 1,25(OH)2D3 was found to decrease cellular proliferative activity, reduce c-myc-mRNA, and induce the expression of monocyte-specific cell surface antigen 63D3. This suggests the possibility of using 1,25(OH)2D3 or one of its analogs as an antiproliferative agent for the treatment of some leukemias and other malignant disorders. Most cells and tissues in the human body possess VDR and are therefore potential target tissues for 1,25(OH)2D3. Although there is very strong evidence in vitro and in vivo that 1,25(OH)2D3 can have a wide range of noncalcemic activities that affect the function of the immune system, skin, gonads, prostate gland, brain, skeletal and smooth muscle, and pancreas, the true physiologic function of 1,25(OH)2D3 is not well understood." @default.
• W3023555422 created "2020-05-13" @default.
• W3023555422 creator A5053935340 @default.
• W3023555422 date "2002-01-01" @default.
• W3023555422 modified "2023-09-27" @default.
• W3023555422 title "Photobiology and Noncalcemic Actions of Vitamin D" @default.
• W3023555422 cites W1506296246 @default.
• W3023555422 cites W1520833254 @default.
• W3023555422 cites W1523490315 @default.
• W3023555422 cites W1531695673 @default.
• W3023555422 cites W1748624304 @default.
• W3023555422 cites W1963726681 @default.
• W3023555422 cites W1965692086 @default.
• W3023555422 cites W1966237185 @default.
• W3023555422 cites W1967245452 @default.
• W3023555422 cites W1967386430 @default.
• W3023555422 cites W1970366802 @default.
• W3023555422 cites W1971864304 @default.
• W3023555422 cites W1975524677 @default.
• W3023555422 cites W1975818881 @default.
• W3023555422 cites W1975876211 @default.
• W3023555422 cites W1984304541 @default.
• W3023555422 cites W1984372852 @default.
• W3023555422 cites W1985664413 @default.
• W3023555422 cites W1988738875 @default.
• W3023555422 cites W1988985660 @default.
• W3023555422 cites W1992847499 @default.
• W3023555422 cites W1996055041 @default.
• W3023555422 cites W1997429630 @default.
• W3023555422 cites W1999141041 @default.
• W3023555422 cites W1999215685 @default.
• W3023555422 cites W2002961303 @default.
• W3023555422 cites W2003412171 @default.
• W3023555422 cites W2003465607 @default.
• W3023555422 cites W2003575314 @default.
• W3023555422 cites W2013248652 @default.
• W3023555422 cites W2017652491 @default.
• W3023555422 cites W2018006483 @default.
• W3023555422 cites W2019183743 @default.
• W3023555422 cites W2021409342 @default.
• W3023555422 cites W2024357543 @default.
• W3023555422 cites W2030627408 @default.
• W3023555422 cites W2033660218 @default.
• W3023555422 cites W2034197398 @default.
• W3023555422 cites W2034725130 @default.
• W3023555422 cites W2037320597 @default.
• W3023555422 cites W2049280452 @default.
• W3023555422 cites W2054647786 @default.
• W3023555422 cites W2056319477 @default.
• W3023555422 cites W2056503051 @default.
• W3023555422 cites W2056996122 @default.
• W3023555422 cites W2057182956 @default.
• W3023555422 cites W2057716888 @default.
• W3023555422 cites W2058072711 @default.
• W3023555422 cites W2058082527 @default.
• W3023555422 cites W2060776958 @default.
• W3023555422 cites W2065897358 @default.
• W3023555422 cites W2069861569 @default.
• W3023555422 cites W2071921882 @default.
• W3023555422 cites W2077420287 @default.
• W3023555422 cites W2077469587 @default.
• W3023555422 cites W2078460206 @default.
• W3023555422 cites W2080844332 @default.
• W3023555422 cites W2083717612 @default.
• W3023555422 cites W2083984359 @default.
• W3023555422 cites W2084949658 @default.
• W3023555422 cites W2086203532 @default.
• W3023555422 cites W2088001182 @default.
• W3023555422 cites W2090017418 @default.
• W3023555422 cites W2091347687 @default.
• W3023555422 cites W2092410657 @default.
• W3023555422 cites W2094493372 @default.
• W3023555422 cites W2103119277 @default.
• W3023555422 cites W2108426329 @default.
• W3023555422 cites W2116594884 @default.
• W3023555422 cites W2124352477 @default.
• W3023555422 cites W2140677830 @default.
• W3023555422 cites W2143458310 @default.
• W3023555422 cites W2157855487 @default.
• W3023555422 cites W2158651421 @default.
• W3023555422 cites W2162463371 @default.
• W3023555422 cites W2167132436 @default.
• W3023555422 cites W2321700151 @default.
• W3023555422 cites W2336000481 @default.
• W3023555422 doi "https://doi.org/10.1016/b978-012098652-1.50135-9" @default.
• W3023555422 hasPublicationYear "2002" @default.
• W3023555422 type Work @default.
• W3023555422 sameAs 3023555422 @default.
• W3023555422 citedByCount "0" @default.
• W3023555422 crossrefType "book-chapter" @default.
• W3023555422 hasAuthorship W3023555422A5053935340 @default.
• W3023555422 hasConcept C121332964 @default.
• W3023555422 hasConcept C124490489 @default.
• W3023555422 hasConcept C126661725 @default.
• W3023555422 hasConcept C1276947 @default.
• W3023555422 hasConcept C134018914 @default.
• W3023555422 hasConcept C150903083 @default.
• W3023555422 hasConcept C15095095 @default.
• W3023555422 hasConcept C161790260 @default.
• W3023555422 hasConcept C170853661 @default.

• next