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- W3023557829 endingPage "56" @default.
- W3023557829 startingPage "47" @default.
- W3023557829 abstract "Stroke is the third leading cause of death and the leading cause of long-term disability, with very few effective treatments and limited progress in the effort to search for novel therapeutic approaches. The phenomenon that a sublethal ischemic insult induces protection against a subsequent severe ischemia, termed ischemic preconditioning (IPC), represents an endogenous protective approach against ischemic brain injury, and may direct a breakthrough to future therapeutic strategies. It is broadly accepted that new protein synthesis is required for IPC-mediated long-term neuroprotection; however, their relative regulatory mechanisms are poorly understood. In the present review, we summarize genomic-based studies on alterations in gene expression and protein synthesis, particularly categorizing potential pathways regulated by IPC. We also review the role of epigenetics, an inheritable genetic regulatory mechanism without changes in DNA sequence, in IPC-mediated neuroprotection." @default.
- W3023557829 created "2020-05-13" @default.
- W3023557829 creator A5004341581 @default.
- W3023557829 creator A5041490775 @default.
- W3023557829 creator A5052274720 @default.
- W3023557829 date "2017-12-01" @default.
- W3023557829 modified "2023-09-27" @default.
- W3023557829 title "Regulation of gene expression in ischemic preconditioning in the brain." @default.
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