FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023593630> ?p ?o ?g. }

• W3023593630 endingPage "112" @default.
• W3023593630 startingPage "67" @default.
• W3023593630 abstract "Cancer is a major cause of deaths throughout the world. According to World Health Organization, cancer lead to the loss of about 9.6 million lives in the year 2018 with low and middle income countries accounting for 70% of these deaths. With its ability to grow in an uncontrolled manner and spreading out to different sites in the body, cancer is seen as that dreaded disease with no cure or treatment. Several promising cancer chemotherapeutic advancements have emerged but these came along with unavoidable limitations like toxicity, limits on the administered dosage as well as affordability for the people who most need them. Natural products with anticancer potential have also emerged as an immensely attractive option to treat cancer. The use of natural products has been credited to doubling of human life span in twentieth century. Furthermore, of all the anti-cancer agents approved and pre-new drug application candidates till date, more than 60% are of natural origin or a derivative thereof. However, an estimated 4 in 10 of the new chemical entity proposed against cancer turns out to be lipophilic. Problems of low aqueous solubility, low bioavailability and non-specific action still pose as major stumbling blocks in their advancement. Recently, polymeric nanocarriers have been used to deliver cancer chemotherapeutics to circumvent the associated limitations and improve their efficacy. Polymers like polylactic acid/poly lactic-co-glycolic acid are have a long history of use in medical field. These are safe and biodegradable with about 20 products approved by the Food and Drug Administration and European Medicine Agency for use in humans. The polymeric nanocarriers with their versatility offer solution to many of the hurdles of natural product delivery for cancer chemotherapy.In this chapter, we briefly discuss about the characteristics acquired by a cell progressing towards carcinogenesis. We then explore some of the conventional chemotherapeutic strategies that have been in use for the treatment of cancer. Moving further we discuss about the emergence of natural products in the cancer chemotherapy field. We examine how their non-toxic nature and ability to target multiple mechanisms has garnered attention. We conclude by reviewing about the use of polymeric nanocarriers to deliver natural products. We discuss some of the advantages offered by them and how they can be used to circumvent the limitations associated with the delivery of natural products for cancer chemotherapy. With this chapter we hope to shed light on how delivering anticancer natural products via polymeric nanocarriers can offer a safe and patient compliant strategy for the treatment of cancer." @default.
• W3023593630 created "2020-05-13" @default.
• W3023593630 creator A5011274283 @default.
• W3023593630 creator A5013669562 @default.
• W3023593630 creator A5020779635 @default.
• W3023593630 creator A5057741798 @default.
• W3023593630 creator A5087302432 @default.
• W3023593630 date "2020-01-01" @default.
• W3023593630 modified "2023-09-24" @default.
• W3023593630 title "Delivery of Natural Products Using Polymeric Particles for Cancer Chemotherapeutics" @default.
• W3023593630 cites W1497663772 @default.
• W3023593630 cites W1543678657 @default.
• W3023593630 cites W1569631204 @default.
• W3023593630 cites W1781591963 @default.
• W3023593630 cites W1842762049 @default.
• W3023593630 cites W1867494357 @default.
• W3023593630 cites W1959848155 @default.
• W3023593630 cites W1964081206 @default.
• W3023593630 cites W1967532587 @default.
• W3023593630 cites W1970396523 @default.
• W3023593630 cites W1972739162 @default.
• W3023593630 cites W1973109316 @default.
• W3023593630 cites W1982037430 @default.
• W3023593630 cites W1982262593 @default.
• W3023593630 cites W1984264526 @default.
• W3023593630 cites W1985213483 @default.
• W3023593630 cites W1992708996 @default.
• W3023593630 cites W2001106708 @default.
• W3023593630 cites W2005138952 @default.
• W3023593630 cites W2005334224 @default.
• W3023593630 cites W2005961460 @default.
• W3023593630 cites W2006901327 @default.
• W3023593630 cites W2007586888 @default.
• W3023593630 cites W2010114371 @default.
• W3023593630 cites W2012117840 @default.
• W3023593630 cites W2012124753 @default.
• W3023593630 cites W2012170303 @default.
• W3023593630 cites W2015184364 @default.
• W3023593630 cites W2017451930 @default.
• W3023593630 cites W2017920747 @default.
• W3023593630 cites W2018116689 @default.
• W3023593630 cites W2020398834 @default.
• W3023593630 cites W2025382905 @default.
• W3023593630 cites W2028160054 @default.
• W3023593630 cites W2028415754 @default.
• W3023593630 cites W2030698160 @default.
• W3023593630 cites W2030951969 @default.
• W3023593630 cites W2033281188 @default.
• W3023593630 cites W204036265 @default.
• W3023593630 cites W2042922488 @default.
• W3023593630 cites W2045413888 @default.
• W3023593630 cites W2047051739 @default.
• W3023593630 cites W2047955502 @default.
• W3023593630 cites W2051190668 @default.
• W3023593630 cites W2053134659 @default.
• W3023593630 cites W2053300345 @default.
• W3023593630 cites W2058228760 @default.
• W3023593630 cites W2058648826 @default.
• W3023593630 cites W2060918390 @default.
• W3023593630 cites W2062166266 @default.
• W3023593630 cites W2071333117 @default.
• W3023593630 cites W2073131803 @default.
• W3023593630 cites W2074360914 @default.
• W3023593630 cites W2074831400 @default.
• W3023593630 cites W2075757507 @default.
• W3023593630 cites W2076908478 @default.
• W3023593630 cites W2078686061 @default.
• W3023593630 cites W2080631994 @default.
• W3023593630 cites W2082389903 @default.
• W3023593630 cites W2084592362 @default.
• W3023593630 cites W2087027618 @default.
• W3023593630 cites W2090719490 @default.
• W3023593630 cites W2094813669 @default.
• W3023593630 cites W2100173894 @default.
• W3023593630 cites W2102301778 @default.
• W3023593630 cites W2105213327 @default.
• W3023593630 cites W2109034822 @default.
• W3023593630 cites W2110075349 @default.
• W3023593630 cites W2114459411 @default.
• W3023593630 cites W2114550587 @default.
• W3023593630 cites W2117142296 @default.
• W3023593630 cites W2117692326 @default.
• W3023593630 cites W2118278569 @default.
• W3023593630 cites W2119657212 @default.
• W3023593630 cites W2121325790 @default.
• W3023593630 cites W2122513656 @default.
• W3023593630 cites W2125552828 @default.
• W3023593630 cites W2125970092 @default.
• W3023593630 cites W2132620319 @default.
• W3023593630 cites W2134726513 @default.
• W3023593630 cites W2136280424 @default.
• W3023593630 cites W2140387479 @default.
• W3023593630 cites W2140912399 @default.
• W3023593630 cites W2141815918 @default.
• W3023593630 cites W2143463421 @default.
• W3023593630 cites W2144264206 @default.
• W3023593630 cites W2146414563 @default.
• W3023593630 cites W2149504763 @default.

• next