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• W3023612626 abstract "Resolvins are members of a new category of inflammation-reducing mediators derived from omega-3-fatty acids such as those found in certain fish. These lipid compounds were initially identified in inflammatory exudates and have a wide range of modulating effects. Prior investigations have demonstrated their ability to decrease polymorphonuclear recruitment and limit ischemia-reperfusion damage, neovascularization, and release of inflammatory cytokines from macrophages.1Recchiuti A. Resolvin D1 and its GPCRs in resolution circuits of inflammation.Prostaglandins Other Lipid Mediat. 2013; 107: 64-76Crossref PubMed Scopus (35) Google Scholar Innovative studies from Dr Conte's group2Akagi D. Chen M. Toy R. Chatterjee A. Conte M.S. Systemic delivery of proresolving lipid mediators resolvin D2 and maresin 1 attenuates intimal hyperplasia in mice.FASEB J. 2015; 29: 2504-2513Crossref PubMed Scopus (77) Google Scholar, 3Miyahara T. Runge S. Chatterjee A. Chen M. Mottola G. Fitzgerald J.M. et al.D-series resolvin attenuates vascular smooth muscle cell activation and neointimal hyperplasia following vascular injury.FASEB. 2013; 27: 2220-2232Crossref PubMed Scopus (98) Google Scholar has previously shown that systemic administration of such specialized proresolving lipid mediators is capable of multiple beneficial effects after arterial injury, including reducing smooth muscle cell responses, decreasing superoxide production and proinflammatory gene expression, and decreasing neointimal hyperplasia. In this report, Wu et al extend their findings to the rat carotid angioplasty model and introduced a novel method for periadventitial delivery. They show that by locally delivering resolvin D1 via thin biodegradable poly(lactic-co-glycolic acid) wraps, it is possible to reduce neointima formation by >50%. Importantly, the authors note minimal toxicity of the compound at the doses used, and this will be of interest for future clinical application. Such findings nicely demonstrate the potential of direct treatment methods to improve patency after open surgical procedures. Several questions remain before full transition to the clinics can begin. The optimal dose and method of delivery will need to be determined, and the need for sustained release vs single application strategies will require definition. Because one of its primary mechanisms involves decreasing inflammatory cell infiltrate, the potential for inhibitory effects on wound healing and infection will need to be investigated. Nevertheless, such promising findings support continued efforts to overcome the frustrating obstacle of postoperative intimal hyperplasia so that we can improve long-term outcomes in our vascular patients. Perivascular delivery of resolvin D1 inhibits neointimal hyperplasia in a rat model of arterial injuryJournal of Vascular SurgeryVol. 65Issue 1PreviewLipid mediators derived from omega-3 polyunsaturated fatty acids such as resolvin D1 (RvD1) accelerate the resolution of inflammation and have potential as vascular therapeutics. The objective of this study was to evaluate local perivascular delivery of RvD1 as a means to attenuate neointimal hyperplasia in a rat model of arterial injury. Full-Text PDF Open Archive" @default.
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• W3023612626 date "2017-01-01" @default.
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• W3023612626 doi "https://doi.org/10.1016/j.jvs.2016.10.071" @default.
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