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• W3023641363 abstract "This chapter addresses the need for the aseptic operation of fermentation processes and the procedures adopted to achieve it—the sterilization of the process plant, the medium and air supply. The kinetics and scale-up of medium sterilization by wet heat are discussed in terms of specific death rate (k), Del factor (▿), and nutrient quality criterion (Q) as well as in terms of decimal reduction time (D), Z value, F0 value, and R0 value. The design and operation of batch and continuous medium sterilization systems are compared as means of sterilizing fermentation media, feeds, and liquid wastes. The theory of fixed pore and nonfixed pore filtration is addressed and their application to the sterilization of heat-labile solutions is discussed as well as the methods used to size such filters. Finally, the sterilization of both fermenter inlet and exhaust air is discussed." @default.
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• W3023641363 date "2017-01-01" @default.
• W3023641363 modified "2023-09-25" @default.
• W3023641363 title "Sterilization" @default.
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• W3023641363 doi "https://doi.org/10.1016/b978-0-08-099953-1.00005-3" @default.
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