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- W3023642241 endingPage "536" @default.
- W3023642241 startingPage "516" @default.
- W3023642241 abstract "Oxygen is both vital and toxic to life. Molecular oxygen is the most used substrate in the human body and is required for several hundred diverse biochemical reactions. The discovery of the PHD-HIF-pVHL system revolutionized our fundamental understanding of oxygen sensing and cellular adaptations to hypoxia. It deepened our knowledge of the biochemical underpinnings of numerous diseases, ranging from anemia to cancer. Cellular dysfunction and tissue pathology can result from a mismatch of oxygen supply and demand. Recent work has shown that mitochondrial disease models display tissue hyperoxia and that disease pathology can be reversed by normalization of excess oxygen, suggesting that certain disease states can potentially be treated by modulating oxygen levels. In this review, we describe cellular and organismal mechanisms of oxygen sensing and adaptation. We provide a revitalized framework for understanding pathologies of too little or too much oxygen." @default.
- W3023642241 created "2020-05-13" @default.
- W3023642241 creator A5022136914 @default.
- W3023642241 creator A5047321670 @default.
- W3023642241 date "2020-07-01" @default.
- W3023642241 modified "2023-10-18" @default.
- W3023642241 title "Turning the Oxygen Dial: Balancing the Highs and Lows" @default.
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