FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023646335> ?p ?o ?g. }

• W3023646335 endingPage "114019" @default.
• W3023646335 startingPage "114019" @default.
• W3023646335 abstract "Nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR) are effective substrates for NAD synthesis, which may act as vasoprotective agents. Here, we characterize the effects of NMN and NR on endothelial inflammation and dysfunction and test the involvement of CD73 in these effects. The effect of NMN and NR on IL1β- or TNFα-induced endothelial inflammation (ICAM1 and vWF expression), intracellular NAD concentration and NAD-related enzyme expression (NAMPT, CD38, CD73), were studied in HAECs. The effect of NMN and NR on angiotensin II-induced impairment of endothelium-dependent vasodilation was analyzed in murine aortic rings. The involvement of CD73 in NMN and NR effects was tested using CD73 inhibitor-AOPCP, or CD73−/− mice. 24 h-incubation with NMN and NR induced anti-inflammatory effects in HAEC stimulated by IL1β or TNFα, as evidenced by a reduction in ICAM1 and vWF expression. Effects of exogenous NMN but not NR was abrogated in the presence of AOPCP, that efficiently inhibited extracellular endothelial conversion of NMN to NR, without a significant effect on the metabolism of NMN to NA. Surprisingly, intracellular NAD concentration increased in HAEC stimulated by IL1β or TNFα and this effect was associated with upregulation of NAMPT and CD73, whereas changes in CD38 expression were less pronounced. NMN and NR further increased NAD in IL1β-stimulated HAECs and AOPCP diminished NMN-induced increase in NAD, without an effect on NR-induced response. In ex vivo aortic rings stimulated with angiotensin II for 24 h, NO-dependent vasorelaxation induced by acetylcholine was impaired. NMN and NR, both prevented Ang II-induced endothelial dysfunction in the aorta. In aortic rings taken from CD73−/− mice NMN effect was lost, whereas NR effect was preserved. NMN and NR modulate intracellular NAD content in endothelium, inhibit endothelial inflammation and improve NO-dependent function by CD73-dependent and independent pathways, respectively. Extracellular conversion of NMN to NR by CD73 localized in the luminal surface of endothelial cells represent important vasoprotective mechanisms to maintain intracellular NAD." @default.
• W3023646335 created "2020-05-13" @default.
• W3023646335 creator A5013119744 @default.
• W3023646335 creator A5021978069 @default.
• W3023646335 creator A5031283150 @default.
• W3023646335 creator A5045778168 @default.
• W3023646335 creator A5046550706 @default.
• W3023646335 creator A5057414547 @default.
• W3023646335 creator A5073363845 @default.
• W3023646335 date "2020-08-01" @default.
• W3023646335 modified "2023-10-18" @default.
• W3023646335 title "Reversal of endothelial dysfunction by nicotinamide mononucleotide via extracellular conversion to nicotinamide riboside" @default.
• W3023646335 cites W1526965676 @default.
• W3023646335 cites W1796529988 @default.
• W3023646335 cites W1969233019 @default.
• W3023646335 cites W1974409640 @default.
• W3023646335 cites W1983577961 @default.
• W3023646335 cites W1989674299 @default.
• W3023646335 cites W1991806243 @default.
• W3023646335 cites W2002811789 @default.
• W3023646335 cites W2012919786 @default.
• W3023646335 cites W2013844116 @default.
• W3023646335 cites W2025316183 @default.
• W3023646335 cites W2038011036 @default.
• W3023646335 cites W2051108888 @default.
• W3023646335 cites W2082393205 @default.
• W3023646335 cites W2087888115 @default.
• W3023646335 cites W2102260696 @default.
• W3023646335 cites W2108067308 @default.
• W3023646335 cites W2108252736 @default.
• W3023646335 cites W2111172038 @default.
• W3023646335 cites W2131005104 @default.
• W3023646335 cites W2144174481 @default.
• W3023646335 cites W2157296254 @default.
• W3023646335 cites W2163282809 @default.
• W3023646335 cites W2164236823 @default.
• W3023646335 cites W2166460475 @default.
• W3023646335 cites W2166956025 @default.
• W3023646335 cites W2168786562 @default.
• W3023646335 cites W2171863507 @default.
• W3023646335 cites W2174179366 @default.
• W3023646335 cites W2263792530 @default.
• W3023646335 cites W2272552897 @default.
• W3023646335 cites W2296761075 @default.
• W3023646335 cites W2320190638 @default.
• W3023646335 cites W2333241266 @default.
• W3023646335 cites W2343462384 @default.
• W3023646335 cites W2344675239 @default.
• W3023646335 cites W2344962765 @default.
• W3023646335 cites W2427895239 @default.
• W3023646335 cites W2466482160 @default.
• W3023646335 cites W2530388030 @default.
• W3023646335 cites W2531686927 @default.
• W3023646335 cites W2546015443 @default.
• W3023646335 cites W2547963687 @default.
• W3023646335 cites W2559115554 @default.
• W3023646335 cites W2618669287 @default.
• W3023646335 cites W2732717343 @default.
• W3023646335 cites W2775008495 @default.
• W3023646335 cites W2775095764 @default.
• W3023646335 cites W2803204535 @default.
• W3023646335 cites W2804258930 @default.
• W3023646335 cites W2890862278 @default.
• W3023646335 cites W2908304123 @default.
• W3023646335 cites W2910735407 @default.
• W3023646335 cites W2913106502 @default.
• W3023646335 cites W2916140160 @default.
• W3023646335 cites W2922173223 @default.
• W3023646335 cites W2923560995 @default.
• W3023646335 cites W2944004185 @default.
• W3023646335 cites W2946122007 @default.
• W3023646335 cites W2947205202 @default.
• W3023646335 cites W2947902196 @default.
• W3023646335 cites W317961154 @default.
• W3023646335 doi "https://doi.org/10.1016/j.bcp.2020.114019" @default.
• W3023646335 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32389638" @default.
• W3023646335 hasPublicationYear "2020" @default.
• W3023646335 type Work @default.
• W3023646335 sameAs 3023646335 @default.
• W3023646335 citedByCount "44" @default.
• W3023646335 countsByYear W30236463352020 @default.
• W3023646335 countsByYear W30236463352021 @default.
• W3023646335 countsByYear W30236463352022 @default.
• W3023646335 countsByYear W30236463352023 @default.
• W3023646335 crossrefType "journal-article" @default.
• W3023646335 hasAuthorship W3023646335A5013119744 @default.
• W3023646335 hasAuthorship W3023646335A5021978069 @default.
• W3023646335 hasAuthorship W3023646335A5031283150 @default.
• W3023646335 hasAuthorship W3023646335A5045778168 @default.
• W3023646335 hasAuthorship W3023646335A5046550706 @default.
• W3023646335 hasAuthorship W3023646335A5057414547 @default.
• W3023646335 hasAuthorship W3023646335A5073363845 @default.
• W3023646335 hasBestOaLocation W30236463351 @default.
• W3023646335 hasConcept C10205521 @default.
• W3023646335 hasConcept C159912055 @default.
• W3023646335 hasConcept C181199279 @default.
• W3023646335 hasConcept C185592680 @default.
• W3023646335 hasConcept C2776901170 @default.

• next