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- W3023646866 abstract "Abstract Aronia (Aronia melanocarpa) contains many polyphenols including cyanidin-3,5-diglucoside, and these polyphenols have beneficial effects on lifestyle-related diseases such as type 2 diabetes and obesity. In type 2 diabetes and obesity model KKAy mice, drinking water supplemented with aronia juice reduced blood glucose levels partly through inhibition of dipeptidyl peptidase IV (DPP IV) activity by cyanidin-3,5-diglucoside. The objective of this study was to find α-glucosidase inhibitors in aronia juice. Polyphenols in aronia juice were first separated using flash chromatography on a reversed-phase column. The fraction with inhibitory activity was further separated using reversed-phase HPLC. Two peak fractions showed inhibitory activity. LC-MS/MS analysis of the fractions indicated that they contained 3-caffeoylquinic acid (3-CQA) and 4-caffeoylquinic acid (4-CQA), respectively. Both CQAs also inhibited DPP IV activity. The results suggest that caffeoylquinic acids in aronia juice are important for the amelioration of type 2 diabetes by the juice." @default.
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- W3023646866 date "2020-07-01" @default.
- W3023646866 modified "2023-09-29" @default.
- W3023646866 title "Caffeoylquinic acids from aronia juice inhibit both dipeptidyl peptidase IV and α-glucosidase activities" @default.
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- W3023646866 doi "https://doi.org/10.1016/j.lwt.2020.109544" @default.
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