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- W3023646904 abstract "George Herbert Hitchings and Gertrude Elion identified, and developed three important antimicrobial agents: pyrimethamine, trimethoprim, and acyclovir, using an efficient and rational methodology. Pyrimethamine is a chemotherapeutic agent that interferes with the synthesis of folic acid, and the derivatives required for the synthesis of nucleic acids. Pyrimethamine is used in combination with a sulfonamide, thus providing inhibition of two sequential steps in folic acid metabolism. Pyrimethamine plus a sulfa is used for the treatment of malaria, and toxoplasmosis, a protozoan infection which is of particular importance in causing congenital disease. Trimethoprim in combination with sulfamethoxazole is used to treat bacterial infections of the urinary tract, venereal, and respiratory infections. Acyclovir, is an antiviral agent that inhibits the herpes viruses that cause “cold sores,” eye infection, and inflammation of the central nervous system. The antiviral acts by inhibiting DNA polymerase, an enzyme produced, and utilized both by normal cells, and herpes viruses to synthesize DNA." @default.
- W3023646904 created "2020-05-13" @default.
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- W3023646904 date "2005-01-01" @default.
- W3023646904 modified "2023-09-27" @default.
- W3023646904 title "CHEMOTHERAPEUTIC AGENTS" @default.
- W3023646904 doi "https://doi.org/10.1016/b978-012369353-2/50012-6" @default.
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