Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023653889> ?p ?o ?g. }
- W3023653889 endingPage "1063" @default.
- W3023653889 startingPage "1052" @default.
- W3023653889 abstract "Despite progress, clinical translation of tissue engineering (TE) products/technologies is limited. A significant effort is underway to develop biomaterials and cells through a minimally modified process for clinical translation of TE products. Recently, bone marrow aspirate (BMA) was identified as an autologous source of cells for TE applications and is currently being tested in clinical therapies, but the isolation methods need improvement to avoid potential for contamination and increase progenitor cell yield. To address these issues, we reproducibly processed human peripheral blood (PB) and BMA to develop autologously derived biomaterials and cells. We demonstrated PB-derived biomaterial/gel cross-linking and fibrin gel formation with varied gelation times as well as biocompatibility through support of human bone marrow-derived stem cell survival and growth in vitro. Next, we established a plastic culture-free process that concentrates and increases the yield of CD146+/CD271+ early mesenchymal progenitor cells in BMA (concentrated BMA [cBMA]). cBMA exhibited increased colony formation and multipotency (including chondrogenic differentiation) in vitro compared with standard BMA. PB-derived gels encapsulated with cBMA also demonstrated increased cell proliferation and enhanced mineralization when assessed for bone TE in vitro. This strategy can potentially be developed for use in any tissue regeneration application; however, bone regeneration was used as a test bed for this study." @default.
- W3023653889 created "2020-05-13" @default.
- W3023653889 creator A5036309473 @default.
- W3023653889 creator A5040960890 @default.
- W3023653889 creator A5050790167 @default.
- W3023653889 creator A5062658027 @default.
- W3023653889 date "2020-10-01" @default.
- W3023653889 modified "2023-10-12" @default.
- W3023653889 title "Evaluation of Autologously Derived Biomaterials and Stem Cells for Bone Tissue Engineering" @default.
- W3023653889 cites W1580844957 @default.
- W3023653889 cites W1584308907 @default.
- W3023653889 cites W1968266650 @default.
- W3023653889 cites W1968488033 @default.
- W3023653889 cites W1979155684 @default.
- W3023653889 cites W1979274462 @default.
- W3023653889 cites W1979320290 @default.
- W3023653889 cites W1982182518 @default.
- W3023653889 cites W1984673782 @default.
- W3023653889 cites W1989126478 @default.
- W3023653889 cites W2001633027 @default.
- W3023653889 cites W2002128589 @default.
- W3023653889 cites W2007310752 @default.
- W3023653889 cites W2009412018 @default.
- W3023653889 cites W2013970253 @default.
- W3023653889 cites W2015257945 @default.
- W3023653889 cites W2015639342 @default.
- W3023653889 cites W2017686962 @default.
- W3023653889 cites W2020700245 @default.
- W3023653889 cites W2021540990 @default.
- W3023653889 cites W2024306244 @default.
- W3023653889 cites W2030922043 @default.
- W3023653889 cites W2031386013 @default.
- W3023653889 cites W2036122797 @default.
- W3023653889 cites W2040426333 @default.
- W3023653889 cites W2042208046 @default.
- W3023653889 cites W2044242789 @default.
- W3023653889 cites W2063947176 @default.
- W3023653889 cites W2066863810 @default.
- W3023653889 cites W2073509408 @default.
- W3023653889 cites W2078332350 @default.
- W3023653889 cites W2089789987 @default.
- W3023653889 cites W2092883023 @default.
- W3023653889 cites W2092987974 @default.
- W3023653889 cites W2096813909 @default.
- W3023653889 cites W2118939519 @default.
- W3023653889 cites W2122366747 @default.
- W3023653889 cites W2126055036 @default.
- W3023653889 cites W2159999899 @default.
- W3023653889 cites W2164661751 @default.
- W3023653889 cites W2168922688 @default.
- W3023653889 cites W2179125235 @default.
- W3023653889 cites W2276609983 @default.
- W3023653889 cites W2280702705 @default.
- W3023653889 cites W2303933008 @default.
- W3023653889 cites W2415458570 @default.
- W3023653889 cites W2430646452 @default.
- W3023653889 cites W2504982951 @default.
- W3023653889 cites W2511878937 @default.
- W3023653889 cites W2522064491 @default.
- W3023653889 cites W2564593849 @default.
- W3023653889 cites W2585241242 @default.
- W3023653889 cites W2596730625 @default.
- W3023653889 cites W2606141198 @default.
- W3023653889 cites W2616461129 @default.
- W3023653889 cites W2621780867 @default.
- W3023653889 cites W2625541251 @default.
- W3023653889 cites W2761405265 @default.
- W3023653889 cites W2773155538 @default.
- W3023653889 cites W2792343683 @default.
- W3023653889 cites W2793777170 @default.
- W3023653889 cites W280054117 @default.
- W3023653889 cites W2801660533 @default.
- W3023653889 cites W2806965041 @default.
- W3023653889 cites W2807578656 @default.
- W3023653889 cites W2887528329 @default.
- W3023653889 cites W2892908040 @default.
- W3023653889 cites W2911900077 @default.
- W3023653889 cites W2925701682 @default.
- W3023653889 cites W2942883314 @default.
- W3023653889 cites W2947612558 @default.
- W3023653889 cites W2984241356 @default.
- W3023653889 cites W3021655083 @default.
- W3023653889 cites W55012891 @default.
- W3023653889 doi "https://doi.org/10.1089/ten.tea.2020.0011" @default.
- W3023653889 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7580602" @default.
- W3023653889 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32375566" @default.
- W3023653889 hasPublicationYear "2020" @default.
- W3023653889 type Work @default.
- W3023653889 sameAs 3023653889 @default.
- W3023653889 citedByCount "5" @default.
- W3023653889 countsByYear W30236538892021 @default.
- W3023653889 countsByYear W30236538892022 @default.
- W3023653889 countsByYear W30236538892023 @default.
- W3023653889 crossrefType "journal-article" @default.
- W3023653889 hasAuthorship W3023653889A5036309473 @default.
- W3023653889 hasAuthorship W3023653889A5040960890 @default.
- W3023653889 hasAuthorship W3023653889A5050790167 @default.
- W3023653889 hasAuthorship W3023653889A5062658027 @default.