FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023657579> ?p ?o ?g. }

• W3023657579 endingPage "888" @default.
• W3023657579 startingPage "883" @default.
• W3023657579 abstract "To investigate the effect of small interfering RNA (siRNA)-mediated silencing of monocarboxylate transporter 1 (MCT1) on the sensitivity of drug-resistant nasopharyngeal carcinoma HNE1/DDP cells to cisplatin (DDP)-induced apoptosis and explore the possible mechanism.The expression of MCT1 was analyzed in HNE1 and HNE1/DDP cells and in HNE1/DDP cells transfected with siRNA using Western blot. MTT assay was used to assess the inhibitory effect of different concentrations of DDP alone or in combination with MCT1 siRNA on the proliferation of HNE1/DDP cells. The apoptosis of cells treated with MCT1 siRNA or/and DDP (8 µmol/L) was assessed using flow cytometry with PI staining, and the mitochondrial membrane potential was detected using JC-1 staining assay; the expressions of Mcl-1, Bak, Bcl-2, and Bax were analyzed using Western blotting.HNE1/DDP cells showed a high expression of MCT1, and MCT1 silencing using siRNA significantly increased the sensitivity of HNE1/DDP cells to DDP (P<0.05) and partly reversed DDP resistance of the cells. MCT1 silencing enhanced the sensitivity of HNE1/DDP cells to DDP-induced apoptosis. Treatment of HNE1/DDP cells with MCT1 siRNA combined with 8 µmol/L DDP for 24 h resulted in an apoptotic rate of (51.23∓2.86)%, significantly higher than that in cells treated with MCT1 siRNA or DDP alone (P<0.05). The combined treatment also reduced the mitochondrial membrane potential, down-regulated the expression of Mcl-1 and Bcl-2, and up-regulated the expression of Bax in the DDP-resistant cells.MCT1 siRNA can enhance the sensitivity of HNE1/DDP cells to DDP-induced apoptosis, the mechanism of which may involve the down-regulation of Mcl-1 and Bcl-2 and up-regulation of Bax expression." @default.
• W3023657579 created "2020-05-13" @default.
• W3023657579 creator A5005459063 @default.
• W3023657579 creator A5008036924 @default.
• W3023657579 creator A5029808077 @default.
• W3023657579 creator A5032483419 @default.
• W3023657579 creator A5047332757 @default.
• W3023657579 creator A5051482334 @default.
• W3023657579 creator A5063867301 @default.
• W3023657579 creator A5070463960 @default.
• W3023657579 date "2017-07-20" @default.
• W3023657579 modified "2023-09-27" @default.
• W3023657579 title "[Small interfering RNA-mediated monocarboxylate transporter 1 silencing enhances sensitivity of nasopharyngeal carcinoma HNE1/DDP cells to cisplatin-induced apoptosis]." @default.
• W3023657579 cites W1005615606 @default.
• W3023657579 cites W1493224624 @default.
• W3023657579 cites W1968355999 @default.
• W3023657579 cites W2033733148 @default.
• W3023657579 cites W2101531870 @default.
• W3023657579 cites W2116188697 @default.
• W3023657579 cites W2143394009 @default.
• W3023657579 cites W2145136453 @default.
• W3023657579 cites W2154152918 @default.
• W3023657579 cites W2344755899 @default.
• W3023657579 cites W2401476024 @default.
• W3023657579 cites W2409670786 @default.
• W3023657579 cites W2430963879 @default.
• W3023657579 cites W2433294466 @default.
• W3023657579 cites W2517490708 @default.
• W3023657579 cites W2536110660 @default.
• W3023657579 cites W2547295886 @default.
• W3023657579 cites W2563106659 @default.
• W3023657579 cites W2567630376 @default.
• W3023657579 cites W2573577038 @default.
• W3023657579 cites W2586935452 @default.
• W3023657579 cites W2587696128 @default.
• W3023657579 cites W2588239956 @default.
• W3023657579 cites W2605834145 @default.
• W3023657579 cites W2610089667 @default.
• W3023657579 cites W633237102 @default.
• W3023657579 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6765516" @default.
• W3023657579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28736362" @default.
• W3023657579 hasPublicationYear "2017" @default.
• W3023657579 type Work @default.
• W3023657579 sameAs 3023657579 @default.
• W3023657579 citedByCount "0" @default.
• W3023657579 crossrefType "journal-article" @default.
• W3023657579 hasAuthorship W3023657579A5005459063 @default.
• W3023657579 hasAuthorship W3023657579A5008036924 @default.
• W3023657579 hasAuthorship W3023657579A5029808077 @default.
• W3023657579 hasAuthorship W3023657579A5032483419 @default.
• W3023657579 hasAuthorship W3023657579A5047332757 @default.
• W3023657579 hasAuthorship W3023657579A5051482334 @default.
• W3023657579 hasAuthorship W3023657579A5063867301 @default.
• W3023657579 hasAuthorship W3023657579A5070463960 @default.
• W3023657579 hasConcept C104317684 @default.
• W3023657579 hasConcept C119056186 @default.
• W3023657579 hasConcept C126322002 @default.
• W3023657579 hasConcept C153911025 @default.
• W3023657579 hasConcept C185592680 @default.
• W3023657579 hasConcept C190283241 @default.
• W3023657579 hasConcept C22615655 @default.
• W3023657579 hasConcept C2776694085 @default.
• W3023657579 hasConcept C2778239845 @default.
• W3023657579 hasConcept C2778997737 @default.
• W3023657579 hasConcept C2780783641 @default.
• W3023657579 hasConcept C502942594 @default.
• W3023657579 hasConcept C509974204 @default.
• W3023657579 hasConcept C54009773 @default.
• W3023657579 hasConcept C54355233 @default.
• W3023657579 hasConcept C553184892 @default.
• W3023657579 hasConcept C55493867 @default.
• W3023657579 hasConcept C71924100 @default.
• W3023657579 hasConcept C81885089 @default.
• W3023657579 hasConcept C85265743 @default.
• W3023657579 hasConcept C86803240 @default.
• W3023657579 hasConceptScore W3023657579C104317684 @default.
• W3023657579 hasConceptScore W3023657579C119056186 @default.
• W3023657579 hasConceptScore W3023657579C126322002 @default.
• W3023657579 hasConceptScore W3023657579C153911025 @default.
• W3023657579 hasConceptScore W3023657579C185592680 @default.
• W3023657579 hasConceptScore W3023657579C190283241 @default.
• W3023657579 hasConceptScore W3023657579C22615655 @default.
• W3023657579 hasConceptScore W3023657579C2776694085 @default.
• W3023657579 hasConceptScore W3023657579C2778239845 @default.
• W3023657579 hasConceptScore W3023657579C2778997737 @default.
• W3023657579 hasConceptScore W3023657579C2780783641 @default.
• W3023657579 hasConceptScore W3023657579C502942594 @default.
• W3023657579 hasConceptScore W3023657579C509974204 @default.
• W3023657579 hasConceptScore W3023657579C54009773 @default.
• W3023657579 hasConceptScore W3023657579C54355233 @default.
• W3023657579 hasConceptScore W3023657579C553184892 @default.
• W3023657579 hasConceptScore W3023657579C55493867 @default.
• W3023657579 hasConceptScore W3023657579C71924100 @default.
• W3023657579 hasConceptScore W3023657579C81885089 @default.
• W3023657579 hasConceptScore W3023657579C85265743 @default.
• W3023657579 hasConceptScore W3023657579C86803240 @default.
• W3023657579 hasIssue "7" @default.
• W3023657579 hasLocation W30236575791 @default.

• next