FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023678045> ?p ?o ?g. }

• W3023678045 endingPage "S506" @default.
• W3023678045 startingPage "S505" @default.
• W3023678045 abstract "To evaluate treatment-related toxicity, disease control, and survival in patients with malignant melanoma of the head and neck with resected regional LN metastases treated with adjuvant hypofractionated IMRT. Between January 2004 and August 2011, 52 patients with malignant melanoma of the head and neck with regional LN metastases were treated with complete resection and adjuvant IMRT at our institution. Patients with known distant metastatic disease at the time of RT (n=6) were excluded, leaving 46 patients for this retrospective analysis. Patients underwent neck dissection (n=42) or wide local excision (n=4) for regional LN involvement at initial diagnosis (n=19) or as recurrence (n=27). All patients had unilateral LN involvement only. Adjuvant IMRT using multiple 6 MV photon beams was delivered twice per week over 2.5 weeks for a total dose of 30 Gray in 5 fractions. The target volume included the ipsilateral (n=44) or bilateral neck (n=2). The primary lesion excision site was typically included in the treatment volume if the interval from excision to RT was less than 2 years. Eighteen patients (39%) received adjuvant sargramostim (GM-CSF). Acute and late toxicities were recorded using the Common Toxicity Criteria for Adverse Events version 4. Site of first recurrence was defined as local-regional (LR, above the clavicles) or distant. Overall survival (OS), disease-free survival (DFS), and disease recurrence risks were determined using Kaplan-Meier (KM) estimates. The median follow-up in living patients was 2.8 years (range, 0.2 - 6.9). Most patients experienced acute grade 1-2 dermatitis (80%) and mucositis (85%). Only 1 patient (2%) experienced acute grade 3 toxicity (parotiditis requiring hospitalization). A total of 8 late grade 2 toxicities requiring medical intervention were observed in 7 patients (16%), including serous otitis media (n=2), soft tissue fibrosis (n=2), xerostomia (n=1), wound dehiscence (n=1), lymphedema (n=1), and hypothyroidism (n=1). No patient experienced grade 3 or higher late toxicity. Site of first recurrence was LR alone (n=5), both LR and distant (n=1), and distant alone (n=25). Five of the 6 LR recurrences were inside the RT target volume. In-field and total LR control at 3 years were 85% and 76%, respectively. Salvage LR treatment included revision neck dissection (n=3) or wide local excision (n=3). OS and DFS at 3 years were 63% and 25%, respectively. In patients with melanoma of the head and neck who underwent lymphadenectomy for regional LN metastases, adjuvant hypofractionated IMRT (30 Gy in 5 fractions) was associated with a high rate of in-field control and a low risk of severe toxicity." @default.
• W3023678045 created "2020-05-13" @default.
• W3023678045 creator A5046426146 @default.
• W3023678045 creator A5053601327 @default.
• W3023678045 creator A5067520533 @default.
• W3023678045 creator A5074277192 @default.
• W3023678045 creator A5079400879 @default.
• W3023678045 creator A5083170859 @default.
• W3023678045 creator A5089766682 @default.
• W3023678045 date "2012-11-01" @default.
• W3023678045 modified "2023-09-27" @default.
• W3023678045 title "Adjuvant Hypofractionated Intensity Modulated Radiation Therapy (IMRT) After Resection of Regional Lymph Node (LN) Metastases in Patients With Malignant Melanoma of the Head and Neck" @default.
• W3023678045 doi "https://doi.org/10.1016/j.ijrobp.2012.07.1348" @default.
• W3023678045 hasPublicationYear "2012" @default.
• W3023678045 type Work @default.
• W3023678045 sameAs 3023678045 @default.
• W3023678045 citedByCount "0" @default.
• W3023678045 crossrefType "journal-article" @default.
• W3023678045 hasAuthorship W3023678045A5046426146 @default.
• W3023678045 hasAuthorship W3023678045A5053601327 @default.
• W3023678045 hasAuthorship W3023678045A5067520533 @default.
• W3023678045 hasAuthorship W3023678045A5074277192 @default.
• W3023678045 hasAuthorship W3023678045A5079400879 @default.
• W3023678045 hasAuthorship W3023678045A5083170859 @default.
• W3023678045 hasAuthorship W3023678045A5089766682 @default.
• W3023678045 hasBestOaLocation W30236780451 @default.
• W3023678045 hasConcept C121608353 @default.
• W3023678045 hasConcept C126322002 @default.
• W3023678045 hasConcept C126838900 @default.
• W3023678045 hasConcept C141071460 @default.
• W3023678045 hasConcept C142724271 @default.
• W3023678045 hasConcept C143998085 @default.
• W3023678045 hasConcept C2776530083 @default.
• W3023678045 hasConcept C2777658100 @default.
• W3023678045 hasConcept C2777863537 @default.
• W3023678045 hasConcept C2778474501 @default.
• W3023678045 hasConcept C2779720271 @default.
• W3023678045 hasConcept C2780849966 @default.
• W3023678045 hasConcept C502942594 @default.
• W3023678045 hasConcept C509974204 @default.
• W3023678045 hasConcept C71924100 @default.
• W3023678045 hasConceptScore W3023678045C121608353 @default.
• W3023678045 hasConceptScore W3023678045C126322002 @default.
• W3023678045 hasConceptScore W3023678045C126838900 @default.
• W3023678045 hasConceptScore W3023678045C141071460 @default.
• W3023678045 hasConceptScore W3023678045C142724271 @default.
• W3023678045 hasConceptScore W3023678045C143998085 @default.
• W3023678045 hasConceptScore W3023678045C2776530083 @default.
• W3023678045 hasConceptScore W3023678045C2777658100 @default.
• W3023678045 hasConceptScore W3023678045C2777863537 @default.
• W3023678045 hasConceptScore W3023678045C2778474501 @default.
• W3023678045 hasConceptScore W3023678045C2779720271 @default.
• W3023678045 hasConceptScore W3023678045C2780849966 @default.
• W3023678045 hasConceptScore W3023678045C502942594 @default.
• W3023678045 hasConceptScore W3023678045C509974204 @default.
• W3023678045 hasConceptScore W3023678045C71924100 @default.
• W3023678045 hasIssue "3" @default.
• W3023678045 hasLocation W30236780451 @default.
• W3023678045 hasOpenAccess W3023678045 @default.
• W3023678045 hasPrimaryLocation W30236780451 @default.
• W3023678045 hasRelatedWork W1972442584 @default.
• W3023678045 hasRelatedWork W2058922894 @default.
• W3023678045 hasRelatedWork W2410322542 @default.
• W3023678045 hasRelatedWork W2416797974 @default.
• W3023678045 hasRelatedWork W2435804119 @default.
• W3023678045 hasRelatedWork W2890449685 @default.
• W3023678045 hasRelatedWork W2892841373 @default.
• W3023678045 hasRelatedWork W3029883122 @default.
• W3023678045 hasRelatedWork W3215709182 @default.
• W3023678045 hasRelatedWork W1990304044 @default.
• W3023678045 hasVolume "84" @default.
• W3023678045 isParatext "false" @default.
• W3023678045 isRetracted "false" @default.
• W3023678045 magId "3023678045" @default.
• W3023678045 workType "article" @default.