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- W3023679596 endingPage "8690" @default.
- W3023679596 startingPage "8681" @default.
- W3023679596 abstract "Halogen bonding (X-bonding) has attracted notable attention among noncovalent interactions. This highly directional attraction between a halogen atom and an electron donor has been exploited in knowledge-based drug design. A great deal of information has been gathered about X-bonds in protein-ligand complexes, as opposed to nucleic acid complexes. Here we provide a thorough analysis of nucleic acid complexes containing either halogenated building blocks or halogenated ligands. We analyzed close contacts between halogens and electron-rich moieties. The phosphate backbone oxygen is clearly the most common halogen acceptor. We identified 21 X-bonds within known structures of nucleic acid complexes. A vast majority of the X-bonds is formed by halogenated nucleobases, such as bromouridine, and feature excellent geometries. Noncovalent ligands have been found to form only interactions with suboptimal interaction geometries. Hence, the first X-bonded nucleic acid binder remains to be discovered." @default.
- W3023679596 created "2020-05-13" @default.
- W3023679596 creator A5010835490 @default.
- W3023679596 creator A5065224837 @default.
- W3023679596 date "2017-06-23" @default.
- W3023679596 modified "2023-09-30" @default.
- W3023679596 title "Halogen Bonding in Nucleic Acid Complexes" @default.
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- W3023679596 doi "https://doi.org/10.1021/acs.jmedchem.7b00329" @default.
- W3023679596 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28605588" @default.
- W3023679596 hasPublicationYear "2017" @default.
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