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- W3023711227 endingPage "3100" @default.
- W3023711227 startingPage "3100" @default.
- W3023711227 abstract "Reactive Oxygen Species or “ROS” encompass several molecules derived from oxygen that can oxidize other molecules and subsequently transition rapidly between species. The key roles of ROS in biological processes are cell signaling, biosynthetic processes, and host defense. In cancer cells, increased ROS production and oxidative stress are instigated by carcinogens, oncogenic mutations, and importantly, metabolic reprograming of the rapidly proliferating cancer cells. Increased ROS production activates myriad downstream survival pathways that further cancer progression and metastasis. In this review, we highlight the relation between ROS, the metabolic programing of cancer, and stromal and immune cells with emphasis on and the transcription machinery involved in redox homeostasis, metabolic programing and malignant phenotype. We also shed light on the therapeutic targeting of metabolic pathways generating ROS as we investigate: Orlistat, Biguandes, AICAR, 2 Deoxyglucose, CPI-613, and Etomoxir." @default.
- W3023711227 created "2020-05-13" @default.
- W3023711227 creator A5007012856 @default.
- W3023711227 creator A5044985459 @default.
- W3023711227 creator A5049910600 @default.
- W3023711227 creator A5076225096 @default.
- W3023711227 creator A5087190533 @default.
- W3023711227 date "2020-04-28" @default.
- W3023711227 modified "2023-10-16" @default.
- W3023711227 title "Redox Homeostasis and Metabolism in Cancer: A Complex Mechanism and Potential Targeted Therapeutics" @default.
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