Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023723382> ?p ?o ?g. }
- W3023723382 endingPage "101756" @default.
- W3023723382 startingPage "101756" @default.
- W3023723382 abstract "Abstract Berberine, an isoquinoline alkaloid derived from Berberis vulgaris and plants of the Ranunculaceae family, elicits a broad range of pharmacological effects, including anticancer properties. However, poor solubility and low bioavailability limit its therapeutic use. In this study, we developed lyotropic liquid crystalline nanoparticles (LCNs) to enhance the solubility of berberine. LCNs were prepared by the ultrasonication method using monoolein, poloxamer 407, polyethylene glycol-400, and Transcutol® HP. The nanoparticles were characterized for size, surface charge, in vitro release, cytotoxicity, and cellular uptake. The average particle size ranged from 186 to 190 nm with cubical shape, and the polydispersity index was lower than 0.2. The zeta potential ranged between −9.3 and −21.9 mV with high drug entrapment efficiency (≥73.8%). The cell viability assay in MCF7 human breast cancer cells revealed that formulations prepared with polyethylene glycol-400 and Transcutol® HP exhibited significantly lower half-maximal inhibitory concentration compared with pure berberine. In cellular uptake assay, berberine concentration in Caco-2 cells was higher for LCNs prepared with Transcutol® HP. In conclusion, LCNs could be a potential carrier for enhancing the solubility and thus improving the anticancer effect of berberine against breast cancer." @default.
- W3023723382 created "2020-05-13" @default.
- W3023723382 creator A5006835687 @default.
- W3023723382 creator A5040497271 @default.
- W3023723382 creator A5049849874 @default.
- W3023723382 creator A5071850536 @default.
- W3023723382 date "2020-06-01" @default.
- W3023723382 modified "2023-09-25" @default.
- W3023723382 title "Encapsulation of berberine into liquid crystalline nanoparticles to enhance its solubility and anticancer activity in MCF7 human breast cancer cells" @default.
- W3023723382 cites W1708964502 @default.
- W3023723382 cites W1799607368 @default.
- W3023723382 cites W1963830953 @default.
- W3023723382 cites W1966163938 @default.
- W3023723382 cites W1980814685 @default.
- W3023723382 cites W1992350696 @default.
- W3023723382 cites W1992548225 @default.
- W3023723382 cites W1994470556 @default.
- W3023723382 cites W1997236186 @default.
- W3023723382 cites W2006053501 @default.
- W3023723382 cites W2022532115 @default.
- W3023723382 cites W2028326656 @default.
- W3023723382 cites W2028339480 @default.
- W3023723382 cites W2042930036 @default.
- W3023723382 cites W2043254322 @default.
- W3023723382 cites W2048628432 @default.
- W3023723382 cites W2060691844 @default.
- W3023723382 cites W2061275221 @default.
- W3023723382 cites W2072191936 @default.
- W3023723382 cites W2072649493 @default.
- W3023723382 cites W2078722368 @default.
- W3023723382 cites W2084768116 @default.
- W3023723382 cites W2085880668 @default.
- W3023723382 cites W2110121513 @default.
- W3023723382 cites W2125393878 @default.
- W3023723382 cites W2146653565 @default.
- W3023723382 cites W2150837746 @default.
- W3023723382 cites W2152603380 @default.
- W3023723382 cites W2164260228 @default.
- W3023723382 cites W2173017159 @default.
- W3023723382 cites W2180467040 @default.
- W3023723382 cites W2270331211 @default.
- W3023723382 cites W2272399875 @default.
- W3023723382 cites W2304528392 @default.
- W3023723382 cites W2306267508 @default.
- W3023723382 cites W2359219670 @default.
- W3023723382 cites W2424155706 @default.
- W3023723382 cites W2429334885 @default.
- W3023723382 cites W2462920850 @default.
- W3023723382 cites W2471370097 @default.
- W3023723382 cites W2474877235 @default.
- W3023723382 cites W2508173956 @default.
- W3023723382 cites W2527497467 @default.
- W3023723382 cites W2573265084 @default.
- W3023723382 cites W2591198701 @default.
- W3023723382 cites W2591223274 @default.
- W3023723382 cites W2606806481 @default.
- W3023723382 cites W2614857817 @default.
- W3023723382 cites W2756539879 @default.
- W3023723382 cites W2789348608 @default.
- W3023723382 cites W2803084733 @default.
- W3023723382 cites W2808722599 @default.
- W3023723382 cites W2810385438 @default.
- W3023723382 cites W2883828549 @default.
- W3023723382 cites W2884422482 @default.
- W3023723382 cites W2900637971 @default.
- W3023723382 cites W2910288321 @default.
- W3023723382 cites W2914728918 @default.
- W3023723382 cites W2933807407 @default.
- W3023723382 cites W2936605978 @default.
- W3023723382 cites W2941295876 @default.
- W3023723382 cites W2943134132 @default.
- W3023723382 cites W2946342106 @default.
- W3023723382 cites W2952816387 @default.
- W3023723382 cites W2969479447 @default.
- W3023723382 cites W2981917056 @default.
- W3023723382 cites W3013101415 @default.
- W3023723382 cites W608457234 @default.
- W3023723382 doi "https://doi.org/10.1016/j.jddst.2020.101756" @default.
- W3023723382 hasPublicationYear "2020" @default.
- W3023723382 type Work @default.
- W3023723382 sameAs 3023723382 @default.
- W3023723382 citedByCount "19" @default.
- W3023723382 countsByYear W30237233822021 @default.
- W3023723382 countsByYear W30237233822022 @default.
- W3023723382 countsByYear W30237233822023 @default.
- W3023723382 crossrefType "journal-article" @default.
- W3023723382 hasAuthorship W3023723382A5006835687 @default.
- W3023723382 hasAuthorship W3023723382A5040497271 @default.
- W3023723382 hasAuthorship W3023723382A5049849874 @default.
- W3023723382 hasAuthorship W3023723382A5071850536 @default.
- W3023723382 hasConcept C109541995 @default.
- W3023723382 hasConcept C121608353 @default.
- W3023723382 hasConcept C126322002 @default.
- W3023723382 hasConcept C155574463 @default.
- W3023723382 hasConcept C155672457 @default.
- W3023723382 hasConcept C171250308 @default.
- W3023723382 hasConcept C178790620 @default.
- W3023723382 hasConcept C185592680 @default.