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- W3023724894 abstract "Background In understanding HPV oncogenesis, several co-factors have been proposed including co-infection with HSV-2. We assessed the relationship between HSV-2 serostatus and HPV-related outcomes in a cohort of quadrivalent HPV-vaccinated women living with HIV (WLWH). Methods In this multi-site study of immunogenicity and efficacy of the qHPV vaccine in WLWH, three doses of qHPV vaccine were offered. Visits were at months -3, 0, 2, 6, 12, 18, 24, and annually thereafter. Participants provided clinical data and cervico-vaginal swabs for HPV DNA detection (Linear array assay) at each visit; baseline serum was tested for HSV-2 type-specific serology (Focus EIA). We used non-parametric statistics to compare the HPV-related outcomes (including 37 high and low-risk HPV types) according to HSV-2 serostatus. Results 151 women aged ≥16 provided baseline serum samples for HSV-2 testing. The predominant regions of origin were Canada (51%) and Africa (30%). At baseline, median age was 39 years (IQR: 34–45), median CD4 count was 500 cells/mm3 (IQR: 382–692), and 70% had an HIV viral load Conclusion HSV-2 seropositivity was common in this cohort of WLWH in Canada, but was not associated with multiple measures of HPV incidence, persistence, and precancerous lesions. Disclosure No significant relationships." @default.
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- W3023724894 date "2019-07-01" @default.
- W3023724894 modified "2023-10-02" @default.
- W3023724894 title "P833 HSV-2 serostatus and HPV incidence, persistence, and precancerous lesions in a cohort of HPV-vaccinated women living with HIV" @default.
- W3023724894 doi "https://doi.org/10.1136/sextrans-2019-sti.878" @default.
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