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- W3023771567 endingPage "1086" @default.
- W3023771567 startingPage "1075" @default.
- W3023771567 abstract "Acute kidney injury (AKI) is common in critically ill children and adults, and sepsis-associated AKI (SA-AKI) is the most frequent cause of AKI in the ICU. To date, no mechanistically targeted therapeutic interventions have been identified. High-throughput omic technologies (e.g., genomics, proteomics, metabolomics, etc.) offer a new angle of approach to achieve this end. In this review, we provide an update on the current understanding of SA-AKI pathophysiology. Omic technologies themselves are briefly discussed to facilitate interpretation of studies using them. We next summarize the body of SA-AKI research to date that has employed omic technologies. Importantly, omic studies are helping to elucidate a pathophysiology of SA-AKI centered around cellular stress responses, metabolic changes, and dysregulation of energy production that underlie its clinical features. Finally, we propose opportunities for future research using clinically relevant animal models, integrating multiple omic technologies and ultimately progressing to translational human studies focusing therapeutic strategies on targeted disease mechanisms." @default.
- W3023771567 created "2020-05-13" @default.
- W3023771567 creator A5012594790 @default.
- W3023771567 creator A5043420154 @default.
- W3023771567 creator A5055061525 @default.
- W3023771567 date "2020-04-30" @default.
- W3023771567 modified "2023-09-29" @default.
- W3023771567 title "The application of omic technologies to research in sepsis-associated acute kidney injury" @default.
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- W3023771567 doi "https://doi.org/10.1007/s00467-020-04557-9" @default.
- W3023771567 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7606209" @default.
- W3023771567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32356189" @default.
- W3023771567 hasPublicationYear "2020" @default.
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