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• W3023795105 abstract "Abstract Heterogeneity of Purkinje cells (PCs) that are arranged into discrete longitudinal stripes in the cerebellar cortex is related to the timing of PC generation. To understand the cerebellar compartmental organization, we mapped the PC birthdate (or differentiation timing) in the entire cerebellar cortex. We used the birthdate-tagging system of neurog2 -CreER (G2A) mice hybridized with the AldocV strain which clarifies the zebrin (aldolase C) longitudinal striped pattern. The pattern of the birthdate-dependent PC distribution was arranged consistently into longitudinally-oriented stripes throughout almost all lobules except for the nodulus, paraflocculus and flocculus, in which distinct stripes were observed.Boundaries of the PC birthdate stripes were found either in the middle or coincided with that of the zebrin stripes. PCs in each birthdate stripe were born in various periods between embryonic day (E) 10.0 and E 13.5. In the vermis, PCs were chronologically distributed from lateral to medial stripes. In the paravermis, PCs of early birthdates were distributed in the long lateral zebrin-positive stripe (stripe 4+//5+) and the medially neighboring narrow zebrin-negative substripe (3d-//e2-), while PCs of late birthdates were distributed in the rest of all paravermal areas. In the hemisphere, PCs of early and late birthdates were intermingled in the majority of areas. The results indicate that the birthdate of a PC is a partial determinant for the zebrin compartment in which it is located. However, the correlation between the PC birthdate and the zebrin compartmentalization is not simple, and distinct among the vermis, paravermis, hemisphere, nodulus, and flocculus. Highlights Birthdates of Purkinje cells (PCs) were mapped on the cerebellar zebrin striped pattern by using Neurog2 -CreER (G2A) mice. The vermis, paravermis, hemisphere, nodulus, and flocculus had distinct longitudinally-striped patterns of PC birthdate distribution. PCs in each birthdate stripe were born in various periods between embryonic day (E) 10.0 and E 13.5. Boundaries of PC birthdate distributions were located at the boundaries of zebrin stripes or in the middle of a zebrin stripe. The results indicate that the PC birthdate is a partial determinant for the zebrin compartment in which a PC is located." @default.
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• W3023795105 date "2020-05-11" @default.
• W3023795105 modified "2023-10-05" @default.
• W3023795105 title "Striped distribution pattern of Purkinje cells of different birthdates in the mouse cerebellar cortex studied with the Neurog2-CreER transgenic line" @default.
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• W3023795105 doi "https://doi.org/10.1101/2020.05.10.086603" @default.
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