Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023827900> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W3023827900 abstract "Linactants, molecules that preferentially localize at the boundary of lipid membrane domains, are attracting considerable attention in recent years due to the recognition that they might regulate lipid-phase separation and thereby modulate membrane morphology. Recent studies have also shown that clustering of some line active agents enhances their ability to modulate membrane curvature. However, the molecular origin of this phenomenon, and the degree to which it impacts biological membranes, remains poorly understood. In this work, we have investigated how linactants induce shape change in multidomain small unilamallar vesicles (SUVs) using extensive dissipative particle dynamics simulations. The linactant was modeled as a two-tailed hybrid lipid with the two tails differing in preference for different lipid domains. We found that addition of a small amount of linactants (∼1%) to a two-domain vesicle leads to substantial reduction in the line tension and neck curvature at the domain boundary. Using cross-linking as a surrogate for clustering, we further show that linactant clusters substantially enhance the boundary preference and therefore the reduction in neck curvature. Moreover, on the basis of analyses of the corresponding changes in the membrane energetics, we highlight how linactants might stabilize nanoscale domains. These results have important implications for the potential existence and physical explanations of nanosized domains in biological membranes." @default.
- W3023827900 created "2020-05-13" @default.
- W3023827900 creator A5073915674 @default.
- W3023827900 creator A5087588530 @default.
- W3023827900 date "2014-01-01" @default.
- W3023827900 modified "2023-09-24" @default.
- W3023827900 title "Modulation of a Small Two-Domain Lipid Vesicle by Linactants" @default.
- W3023827900 hasPublicationYear "2014" @default.
- W3023827900 type Work @default.
- W3023827900 sameAs 3023827900 @default.
- W3023827900 citedByCount "0" @default.
- W3023827900 crossrefType "journal-article" @default.
- W3023827900 hasAuthorship W3023827900A5073915674 @default.
- W3023827900 hasAuthorship W3023827900A5087588530 @default.
- W3023827900 hasConcept C125501631 @default.
- W3023827900 hasConcept C12554922 @default.
- W3023827900 hasConcept C130316041 @default.
- W3023827900 hasConcept C147597530 @default.
- W3023827900 hasConcept C159467904 @default.
- W3023827900 hasConcept C178790620 @default.
- W3023827900 hasConcept C185592680 @default.
- W3023827900 hasConcept C186060115 @default.
- W3023827900 hasConcept C195065555 @default.
- W3023827900 hasConcept C2524010 @default.
- W3023827900 hasConcept C2777278457 @default.
- W3023827900 hasConcept C33923547 @default.
- W3023827900 hasConcept C39944091 @default.
- W3023827900 hasConcept C41625074 @default.
- W3023827900 hasConcept C45594756 @default.
- W3023827900 hasConcept C521977710 @default.
- W3023827900 hasConcept C55493867 @default.
- W3023827900 hasConcept C59593255 @default.
- W3023827900 hasConcept C86803240 @default.
- W3023827900 hasConceptScore W3023827900C125501631 @default.
- W3023827900 hasConceptScore W3023827900C12554922 @default.
- W3023827900 hasConceptScore W3023827900C130316041 @default.
- W3023827900 hasConceptScore W3023827900C147597530 @default.
- W3023827900 hasConceptScore W3023827900C159467904 @default.
- W3023827900 hasConceptScore W3023827900C178790620 @default.
- W3023827900 hasConceptScore W3023827900C185592680 @default.
- W3023827900 hasConceptScore W3023827900C186060115 @default.
- W3023827900 hasConceptScore W3023827900C195065555 @default.
- W3023827900 hasConceptScore W3023827900C2524010 @default.
- W3023827900 hasConceptScore W3023827900C2777278457 @default.
- W3023827900 hasConceptScore W3023827900C33923547 @default.
- W3023827900 hasConceptScore W3023827900C39944091 @default.
- W3023827900 hasConceptScore W3023827900C41625074 @default.
- W3023827900 hasConceptScore W3023827900C45594756 @default.
- W3023827900 hasConceptScore W3023827900C521977710 @default.
- W3023827900 hasConceptScore W3023827900C55493867 @default.
- W3023827900 hasConceptScore W3023827900C59593255 @default.
- W3023827900 hasConceptScore W3023827900C86803240 @default.
- W3023827900 hasLocation W30238279001 @default.
- W3023827900 hasOpenAccess W3023827900 @default.
- W3023827900 hasPrimaryLocation W30238279001 @default.
- W3023827900 hasRelatedWork W1969548207 @default.
- W3023827900 hasRelatedWork W1989939408 @default.
- W3023827900 hasRelatedWork W2017271574 @default.
- W3023827900 hasRelatedWork W2028268935 @default.
- W3023827900 hasRelatedWork W2043535943 @default.
- W3023827900 hasRelatedWork W2047366321 @default.
- W3023827900 hasRelatedWork W2069914828 @default.
- W3023827900 hasRelatedWork W2083694871 @default.
- W3023827900 hasRelatedWork W2084237810 @default.
- W3023827900 hasRelatedWork W2209637969 @default.
- W3023827900 hasRelatedWork W2227162213 @default.
- W3023827900 hasRelatedWork W2326978730 @default.
- W3023827900 hasRelatedWork W2399160802 @default.
- W3023827900 hasRelatedWork W2422276618 @default.
- W3023827900 hasRelatedWork W2546169014 @default.
- W3023827900 hasRelatedWork W2808826667 @default.
- W3023827900 hasRelatedWork W2932644947 @default.
- W3023827900 hasRelatedWork W2987852484 @default.
- W3023827900 hasRelatedWork W30191228 @default.
- W3023827900 hasRelatedWork W3103228167 @default.
- W3023827900 isParatext "false" @default.
- W3023827900 isRetracted "false" @default.
- W3023827900 magId "3023827900" @default.
- W3023827900 workType "article" @default.