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• W3023847071 abstract "Exercise started early after myocardial infarction (MI) improves in vivo cardiac function and myofilament Ca response. We investigated whether this represents partial or complete reversal of cellular remodeling. Mice with MI following LAD ligation were given free access to a running wheel (MIexe, N=8) or housed sedentary (MIsed, N=10) for 8 weeks and compared to sedentary sham-operated animals (SH, N=8). Myocytes were enzymatically isolated from the non-infarcted LV, excluding the border zone. Contraction was measured during electrical field stimulation at 1, 2 and 4 Hz; membrane currents and [Ca2+] were measured under whole-cell patch clamp, with Fluo-3 as Ca2+ indicator, all at 30°C. Data are shown as mean±SEM. Myocytes in MI were significantly longer and further hypertrophied after exercise (165±3 μm in MIexe vs. 148±3 μm in MIsed and 136±2 μm in SH; P<0.05). Cell width was not different. Unloaded cell shortening was significantly reduced in MIsed (at 1 Hz, L/L0= 4.4±0.3% vs. 6.7±0.4% in SH; P<0.05, also at 2 and 4 Hz). Exercise restored cell shortening to SH values (MIex at 1 Hz, L/L0 = 6.4±0.5%). Diastolic Ca2+ levels increased at 4 Hz in all groups but to a lesser extent in MIexe and SH ([Ca2+]rest 128±20 nM in MIexe, 135±27 nM in SH, 199±27 in MIsed; P<0.05). [Ca2+]i transient amplitude, ICaL and SR Ca2+ content were not different between the 3 groups. Ito was significantly reduced in MIsed (27±5 pA/pF vs. 43±7 pA/pF in SH) but was unchanged in MIexe (26±6pA/pF; P<0.05). Early exercise training after MI restores cell contraction to normal values without significant changes in [Ca2+]i consistent with changes at the myofilament level. However, this beneficial effect is not a complete reversal of remodeling as hypertrophy and reduction of Ito are not affected." @default.
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• W3023847071 date "2009-02-01" @default.
• W3023847071 modified "2023-09-26" @default.
• W3023847071 title "Early Exercise Training After Myocardial Infarction Prevents Contractile, But Not Electrical Remodeling Or Hypertrophy" @default.
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• W3023847071 doi "https://doi.org/10.1016/j.bpj.2008.12.2641" @default.
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