Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023908954> ?p ?o ?g. }
- W3023908954 endingPage "393" @default.
- W3023908954 startingPage "384" @default.
- W3023908954 abstract "Aim: The aim of this study was to improve solubility and antitumour ability in vitro of tetrandrine (Tet) via preparing nanosuspensions (NSs).Methods: The Tet-NSs were prepared by wet media milling. The Tet-CCS-NS was prepared with croscarmellose sodium (CCS) as single stabiliser. The Tet-HACC-TPGS-NS was manufactured with D-α-tocopheryl polyethylene glycol 1,000 succinate (TPGS) and hydroponically trimethyl ammonium chloride chitosan (HACC) as combined stabilisers. Physicochemical properties of the NSs such as particle size, surface morphologies, crystallinity and molecular interactions were investigated. In addition, the in vitro dissolution and antitumour activities using A549 human lung cancer cells were evaluated.Results: The mean particle sizes and Zeta potential of freshly prepared Tet-CCS-NS, Tet-HACC-TPGS-NS were 469.1 ± 14nm and 157.3 ± 5nm, −29.4 ± 0.26 mV and 23.3 ± 0.36 mV, respectively. In comparison to pure Tet, the cumulative dissolution of Tet-NSs were increased by 4 ∼ 5 times in 2 h. In vitro antitumour studies on Tet- NSs in A549 cells, the cell survival rate of the Tet-NSs at high concentration (30-50µg/ml) were less than 10% within 48 h. Meanwhile, Tet-NSs were revealed to induce A549 cells apoptosis and promote cell uptake.Conclusion: The present study has proved that the Tet-NSs can increase Tet solubility as well as improve Tet antitumour activity in vitro." @default.
- W3023908954 created "2020-05-13" @default.
- W3023908954 creator A5024867532 @default.
- W3023908954 creator A5050362819 @default.
- W3023908954 creator A5077987647 @default.
- W3023908954 creator A5087567672 @default.
- W3023908954 creator A5088526050 @default.
- W3023908954 creator A5091360395 @default.
- W3023908954 date "2020-05-07" @default.
- W3023908954 modified "2023-10-02" @default.
- W3023908954 title "Preparation and characterisation of tetrandrine nanosuspensions and <i>in vitro</i> estimate antitumour activity on A549 lung cancer cell line" @default.
- W3023908954 cites W1978538658 @default.
- W3023908954 cites W1981505680 @default.
- W3023908954 cites W1993694628 @default.
- W3023908954 cites W2000177666 @default.
- W3023908954 cites W2005070506 @default.
- W3023908954 cites W2019984795 @default.
- W3023908954 cites W2028536670 @default.
- W3023908954 cites W2077488778 @default.
- W3023908954 cites W2079840364 @default.
- W3023908954 cites W2085165694 @default.
- W3023908954 cites W2097502797 @default.
- W3023908954 cites W2117630026 @default.
- W3023908954 cites W2290595093 @default.
- W3023908954 cites W2412202017 @default.
- W3023908954 cites W2414880314 @default.
- W3023908954 cites W2508257700 @default.
- W3023908954 cites W2595806768 @default.
- W3023908954 cites W2600038278 @default.
- W3023908954 cites W2605999908 @default.
- W3023908954 cites W2610788148 @default.
- W3023908954 cites W2644370144 @default.
- W3023908954 cites W2754216856 @default.
- W3023908954 cites W2760165507 @default.
- W3023908954 cites W2768413943 @default.
- W3023908954 cites W2784292743 @default.
- W3023908954 cites W2810875796 @default.
- W3023908954 cites W2883471214 @default.
- W3023908954 cites W2900738736 @default.
- W3023908954 cites W2901436166 @default.
- W3023908954 cites W2901562987 @default.
- W3023908954 cites W2904766142 @default.
- W3023908954 cites W2905479983 @default.
- W3023908954 cites W2906861310 @default.
- W3023908954 cites W2942404546 @default.
- W3023908954 cites W2943606118 @default.
- W3023908954 cites W2943644991 @default.
- W3023908954 cites W2944631149 @default.
- W3023908954 cites W2945078700 @default.
- W3023908954 cites W2961670432 @default.
- W3023908954 cites W2964045009 @default.
- W3023908954 cites W3000136791 @default.
- W3023908954 cites W567781294 @default.
- W3023908954 doi "https://doi.org/10.1080/02652048.2020.1761905" @default.
- W3023908954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32349635" @default.
- W3023908954 hasPublicationYear "2020" @default.
- W3023908954 type Work @default.
- W3023908954 sameAs 3023908954 @default.
- W3023908954 citedByCount "2" @default.
- W3023908954 countsByYear W30239089542021 @default.
- W3023908954 countsByYear W30239089542022 @default.
- W3023908954 crossrefType "journal-article" @default.
- W3023908954 hasAuthorship W3023908954A5024867532 @default.
- W3023908954 hasAuthorship W3023908954A5050362819 @default.
- W3023908954 hasAuthorship W3023908954A5077987647 @default.
- W3023908954 hasAuthorship W3023908954A5087567672 @default.
- W3023908954 hasAuthorship W3023908954A5088526050 @default.
- W3023908954 hasAuthorship W3023908954A5091360395 @default.
- W3023908954 hasConcept C13965031 @default.
- W3023908954 hasConcept C155574463 @default.
- W3023908954 hasConcept C155672457 @default.
- W3023908954 hasConcept C171250308 @default.
- W3023908954 hasConcept C178790620 @default.
- W3023908954 hasConcept C185592680 @default.
- W3023908954 hasConcept C192562407 @default.
- W3023908954 hasConcept C202751555 @default.
- W3023908954 hasConcept C2776964284 @default.
- W3023908954 hasConcept C2779934757 @default.
- W3023908954 hasConcept C55493867 @default.
- W3023908954 hasConcept C71924100 @default.
- W3023908954 hasConcept C81729549 @default.
- W3023908954 hasConcept C86181022 @default.
- W3023908954 hasConcept C88380143 @default.
- W3023908954 hasConcept C98274493 @default.
- W3023908954 hasConceptScore W3023908954C13965031 @default.
- W3023908954 hasConceptScore W3023908954C155574463 @default.
- W3023908954 hasConceptScore W3023908954C155672457 @default.
- W3023908954 hasConceptScore W3023908954C171250308 @default.
- W3023908954 hasConceptScore W3023908954C178790620 @default.
- W3023908954 hasConceptScore W3023908954C185592680 @default.
- W3023908954 hasConceptScore W3023908954C192562407 @default.
- W3023908954 hasConceptScore W3023908954C202751555 @default.
- W3023908954 hasConceptScore W3023908954C2776964284 @default.
- W3023908954 hasConceptScore W3023908954C2779934757 @default.
- W3023908954 hasConceptScore W3023908954C55493867 @default.
- W3023908954 hasConceptScore W3023908954C71924100 @default.
- W3023908954 hasConceptScore W3023908954C81729549 @default.
- W3023908954 hasConceptScore W3023908954C86181022 @default.