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- W3023936218 abstract "This chapter describes the role played by transcriptional factors in osteoblast differentiation and function. Till date, only one transcription factor has been identified that is specifically expressed in cells of the osteoblast lineage, Cbfa1 (core binding factor 1). Cbfa1 expression in osteoblasts is maintained after birth, and Cbfa1 controls the expression of Osteocalcin, for instance, a gene only expressed in fully differentiated osteoblasts. Cbfa1, like all transcription factors belonging to the Runt family, contains a DNA-binding region of 128 amino acids, called the runt domain, followed C-terminally by a proline-serine-threonine-rich region, called the PST domain. The PST domain contributes to the transactivation function of Cbfa1 and contains a short sequence at the C terminus that mediates transcriptional repression through interactions with TLE2. Cbfa1 has two unique domains located at the N terminus that are also involved in activating transcription. One of them, the so-called QA domain, which is rich in glutamine and alanine, prevents heterodimerization of Cbfa1 with Cbfβ, a known partner of other Runt family transcription factors. As haploinsufficiency at the Cbfa1 locus leads to severe skeletal dysplasia, it is conceivable that a moderate increase in the level of Cbfa1 may lead to increased bone formation by activating either, osteoblast differentiation or function. Several lines of evidence suggest that members of the AP-1 family are involved in the regulation of osteoblast differentiation. AP-l binding sites have been found in the promoter regions of several genes expressed in osteoblasts, including alkaline phosphatase and Osteocalcin. Various extracellular signaling molecules, such as TGFβ and PTH, have also been shown to induce the expression of AP-1 components in osteoblastic cells." @default.
- W3023936218 created "2020-05-13" @default.
- W3023936218 creator A5046719684 @default.
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- W3023936218 date "2002-01-01" @default.
- W3023936218 modified "2023-10-05" @default.
- W3023936218 title "Transcriptional Control of Osteoblast Differentiation and Function" @default.
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- W3023936218 doi "https://doi.org/10.1016/b978-012098652-1.50107-4" @default.
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