Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023975397> ?p ?o ?g. }
- W3023975397 endingPage "245" @default.
- W3023975397 startingPage "229" @default.
- W3023975397 abstract "Neuronal cells are sensitive to mechanical properties of extracellular matrix (ECM) such as stiffness and topography. Cells contract and exert a force on ECM to detect the microenvironment, which activates the signaling pathway to influence the cell functions such as differentiation, migration, and proliferation. There are numerous transmembrane proteins that transmit signals; however, integrin and neural cellular adhesion molecules (NCAM) play an important role in sensing the ECM mechanical properties. Mechanotransduction of cell-ECM is the key to understand the influence of ECM stiffness and topography; therefore, in this study, we develop a multiscale computational model to investigate these properties.This model couples the molecular behavior of integrin and NCAM to microscale interactions of neuronal cell and the ECM. We analyze the atomistic/molecular behavior of integrin and NCAM due to mechanical stimuli using steered molecular dynamics. The microscale properties of the neuronal cell and the ECM are simulated using non-linear finite element analysis by applying cell contractility.We predict that by increasing the ECM stiffness, a neuronal cell exerts greater stress on the ECM. However, this stress reaches a saturation value for a threshold stiffness of ECM, and the saturation value is affected by the ECM thickness, topography, and clustering of integrin and NCAMs. Further, the ECM topography leads to asymmetric stress and deformation in the neuronal cell. Predicted stress distribution in neuronal cell and ECM are consistent with experimental results from the literature.The multiscale computational model will guide in selecting the optimal ECM stiffness and topography range for in vitro studies." @default.
- W3023975397 created "2020-05-13" @default.
- W3023975397 creator A5022181757 @default.
- W3023975397 creator A5043797715 @default.
- W3023975397 date "2020-05-04" @default.
- W3023975397 modified "2023-09-29" @default.
- W3023975397 title "A Multiscale Model to Predict Neuronal Cell Deformation with Varying Extracellular Matrix Stiffness and Topography" @default.
- W3023975397 cites W1941245750 @default.
- W3023975397 cites W1971163936 @default.
- W3023975397 cites W1972113511 @default.
- W3023975397 cites W1975713572 @default.
- W3023975397 cites W1976076062 @default.
- W3023975397 cites W1988511295 @default.
- W3023975397 cites W1989042586 @default.
- W3023975397 cites W1991043063 @default.
- W3023975397 cites W1991546772 @default.
- W3023975397 cites W1993488903 @default.
- W3023975397 cites W2003706739 @default.
- W3023975397 cites W2008681436 @default.
- W3023975397 cites W2012100020 @default.
- W3023975397 cites W2015445832 @default.
- W3023975397 cites W2019465613 @default.
- W3023975397 cites W2024081693 @default.
- W3023975397 cites W2027408247 @default.
- W3023975397 cites W2029814263 @default.
- W3023975397 cites W2029987977 @default.
- W3023975397 cites W2030884803 @default.
- W3023975397 cites W2036269346 @default.
- W3023975397 cites W2050333027 @default.
- W3023975397 cites W2058500387 @default.
- W3023975397 cites W2067935721 @default.
- W3023975397 cites W2068343456 @default.
- W3023975397 cites W2068960459 @default.
- W3023975397 cites W2081418737 @default.
- W3023975397 cites W2086486496 @default.
- W3023975397 cites W2091229190 @default.
- W3023975397 cites W2092021110 @default.
- W3023975397 cites W2094573109 @default.
- W3023975397 cites W2096939403 @default.
- W3023975397 cites W2102079607 @default.
- W3023975397 cites W2105614327 @default.
- W3023975397 cites W2109196275 @default.
- W3023975397 cites W2110282630 @default.
- W3023975397 cites W2116517871 @default.
- W3023975397 cites W2123541453 @default.
- W3023975397 cites W2147936936 @default.
- W3023975397 cites W2150353081 @default.
- W3023975397 cites W2153912853 @default.
- W3023975397 cites W2156530903 @default.
- W3023975397 cites W2159492558 @default.
- W3023975397 cites W2161939630 @default.
- W3023975397 cites W2168811660 @default.
- W3023975397 cites W2169047326 @default.
- W3023975397 cites W2169163172 @default.
- W3023975397 cites W2172188060 @default.
- W3023975397 cites W2250284344 @default.
- W3023975397 cites W2268063663 @default.
- W3023975397 cites W2279504920 @default.
- W3023975397 cites W2295769945 @default.
- W3023975397 cites W2312321097 @default.
- W3023975397 cites W2320031737 @default.
- W3023975397 cites W2327893020 @default.
- W3023975397 cites W2340602993 @default.
- W3023975397 cites W2345307871 @default.
- W3023975397 cites W2362504809 @default.
- W3023975397 cites W2411612648 @default.
- W3023975397 cites W2549976854 @default.
- W3023975397 cites W2606324474 @default.
- W3023975397 cites W2712373469 @default.
- W3023975397 cites W2756785816 @default.
- W3023975397 cites W2790632368 @default.
- W3023975397 cites W2887946583 @default.
- W3023975397 cites W2905713548 @default.
- W3023975397 cites W2913201050 @default.
- W3023975397 cites W2974519878 @default.
- W3023975397 cites W3985912 @default.
- W3023975397 cites W413440677 @default.
- W3023975397 cites W656644582 @default.
- W3023975397 doi "https://doi.org/10.1007/s12195-020-00615-2" @default.
- W3023975397 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7225237" @default.
- W3023975397 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32426060" @default.
- W3023975397 hasPublicationYear "2020" @default.
- W3023975397 type Work @default.
- W3023975397 sameAs 3023975397 @default.
- W3023975397 citedByCount "6" @default.
- W3023975397 countsByYear W30239753972021 @default.
- W3023975397 countsByYear W30239753972022 @default.
- W3023975397 countsByYear W30239753972023 @default.
- W3023975397 crossrefType "journal-article" @default.
- W3023975397 hasAuthorship W3023975397A5022181757 @default.
- W3023975397 hasAuthorship W3023975397A5043797715 @default.
- W3023975397 hasBestOaLocation W30239753972 @default.
- W3023975397 hasConcept C12554922 @default.
- W3023975397 hasConcept C145420912 @default.
- W3023975397 hasConcept C1491633281 @default.
- W3023975397 hasConcept C151166631 @default.
- W3023975397 hasConcept C159985019 @default.
- W3023975397 hasConcept C179428855 @default.