Matches in SemOpenAlex for { <https://semopenalex.org/work/W3023979466> ?p ?o ?g. }
Showing items 1 to 64 of
64
with 100 items per page.
- W3023979466 abstract "To design and validate a new screening test for amnestic Mild Cognitive Impairment (MCI) and early Alzheimer's disease (AD) and to investigate the relationship between MAT and in vivo brain metabolite levels. We develop a verbal episodic and semantic memory test: the Memory Alteration Test (MAT). 400 aged individuals from primary care population centers in Barcelona, Spain, 50 patients with MCI according to Petersen et al. criteria, and 66 with early AD (GDS – 4 stage) according to the NINCDS–ADRDA criteria. Proton Magnetic Resonance Image (1H MRS) was performed in 82 subjects: 27 controls, 33 MCI patients and 25 AD patients. The MAT is quick, 5–minutes, easy to administer and to score. MAT mean scores were significantly different between all groups: 41.4 (SD=4.9) in the Primary Care Population, 31.5 (SD=3.9) in the MCI group and 21.8 (SD=4.9) in early AD. A cut–off score of 37 had a sensitivity of 96% and a specificity of 79% for MCI diagnosis (ABC= 0.932). A cut–off score of 28 had a sensitivity of 92% and a specificity of 98% for early AD diagnosis (AUC=0.99) and a sensitivity of 87 % and specificity of 82% to differentiate between MCI and AD patients. Analysis of the 1H MRS for the entire group (controls and patients) revealed a significant negative association between MAT global score and Myoinositol/cr (MI/Cr) ratio from the posterior cingulated (P–CING) (r=–0.51; P<0.001). An association was found between MAT episodic memory items scores and MI/Cr from the P–CING (r=–0.43; P<0.001) and between MAT semantic memory subtests scores and MI/Cr from the P–CING (r=–0.48; P<0.001) and absolute N–acetylaspartate (NAA) from the left temporal pole (r=0.41; P<0.001). A strong association was found between absolute Glutamate (r=–0.71; p<0.001) and NAA levels (r=0.65; p<0.001) from the P–CING and MAT semantic memory subtests scores in the AD group. The MAT provides efficient and valid screening for amnestic MCI and early AD, and discriminates between MCI and early AD patients. MAT score decrease is strongly associated with significant metabolic changes in the brain areas involved in the early AD neurodegenerative process." @default.
- W3023979466 created "2020-05-13" @default.
- W3023979466 creator A5027089756 @default.
- W3023979466 creator A5036068671 @default.
- W3023979466 creator A5040330733 @default.
- W3023979466 creator A5047159861 @default.
- W3023979466 creator A5051198054 @default.
- W3023979466 creator A5052467488 @default.
- W3023979466 date "2006-07-01" @default.
- W3023979466 modified "2023-10-18" @default.
- W3023979466 title "P2-216: Screening for mild cognitive impairment and early AD with MAT (memory alteration test): Biological correlates" @default.
- W3023979466 doi "https://doi.org/10.1016/j.jalz.2006.05.1055" @default.
- W3023979466 hasPublicationYear "2006" @default.
- W3023979466 type Work @default.
- W3023979466 sameAs 3023979466 @default.
- W3023979466 citedByCount "0" @default.
- W3023979466 crossrefType "journal-article" @default.
- W3023979466 hasAuthorship W3023979466A5027089756 @default.
- W3023979466 hasAuthorship W3023979466A5036068671 @default.
- W3023979466 hasAuthorship W3023979466A5040330733 @default.
- W3023979466 hasAuthorship W3023979466A5047159861 @default.
- W3023979466 hasAuthorship W3023979466A5051198054 @default.
- W3023979466 hasAuthorship W3023979466A5052467488 @default.
- W3023979466 hasConcept C126322002 @default.
- W3023979466 hasConcept C126838900 @default.
- W3023979466 hasConcept C143409427 @default.
- W3023979466 hasConcept C2776656118 @default.
- W3023979466 hasConcept C2779134260 @default.
- W3023979466 hasConcept C2908647359 @default.
- W3023979466 hasConcept C2984915365 @default.
- W3023979466 hasConcept C548259974 @default.
- W3023979466 hasConcept C71924100 @default.
- W3023979466 hasConcept C90924648 @default.
- W3023979466 hasConcept C99454951 @default.
- W3023979466 hasConceptScore W3023979466C126322002 @default.
- W3023979466 hasConceptScore W3023979466C126838900 @default.
- W3023979466 hasConceptScore W3023979466C143409427 @default.
- W3023979466 hasConceptScore W3023979466C2776656118 @default.
- W3023979466 hasConceptScore W3023979466C2779134260 @default.
- W3023979466 hasConceptScore W3023979466C2908647359 @default.
- W3023979466 hasConceptScore W3023979466C2984915365 @default.
- W3023979466 hasConceptScore W3023979466C548259974 @default.
- W3023979466 hasConceptScore W3023979466C71924100 @default.
- W3023979466 hasConceptScore W3023979466C90924648 @default.
- W3023979466 hasConceptScore W3023979466C99454951 @default.
- W3023979466 hasIssue "3S_Part_10" @default.
- W3023979466 hasLocation W30239794661 @default.
- W3023979466 hasOpenAccess W3023979466 @default.
- W3023979466 hasPrimaryLocation W30239794661 @default.
- W3023979466 hasRelatedWork W2104404077 @default.
- W3023979466 hasRelatedWork W2114147985 @default.
- W3023979466 hasRelatedWork W2362185074 @default.
- W3023979466 hasRelatedWork W2750616464 @default.
- W3023979466 hasRelatedWork W2765095095 @default.
- W3023979466 hasRelatedWork W2971735620 @default.
- W3023979466 hasRelatedWork W3102635421 @default.
- W3023979466 hasRelatedWork W4238958091 @default.
- W3023979466 hasRelatedWork W4288769387 @default.
- W3023979466 hasRelatedWork W3115448026 @default.
- W3023979466 hasVolume "2" @default.
- W3023979466 isParatext "false" @default.
- W3023979466 isRetracted "false" @default.
- W3023979466 magId "3023979466" @default.
- W3023979466 workType "article" @default.