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- W3023984985 abstract "Engineered proteins are revolutionizing immunotherapy, but advances are still needed to harness their full potential. Traditional protein engineering methods use naturally existing proteins as a starting point, and therefore, are intrinsically limited to small alterations of a protein's natural structure and function. Conversely, computational de novo protein design is free of such limitation, and can produce a virtually infinite number of novel protein sequences, folds, and functions. Recently, we used de novo protein engineering to create Neoleukin-2/15 (Neo-2/15), a protein mimetic of the function of both interleukin-2 (IL-2) and interleukin-15 (IL-15). To our knowledge, Neo-2/15 is the first de novo protein with immunotherapeutic activity, and in murine cancer models, it has demonstrated enhanced therapeutic potency and reduced toxicity compared to IL-2. De novo protein design is already showcasing its tremendous potential for driving the next wave of protein-based therapeutics that are explicitly engineered to treat disease." @default.
- W3023984985 created "2020-05-13" @default.
- W3023984985 creator A5005966052 @default.
- W3023984985 creator A5042927815 @default.
- W3023984985 creator A5075857216 @default.
- W3023984985 creator A5081126784 @default.
- W3023984985 date "2020-06-01" @default.
- W3023984985 modified "2023-10-16" @default.
- W3023984985 title "The advent of de novo proteins for cancer immunotherapy" @default.
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- W3023984985 doi "https://doi.org/10.1016/j.cbpa.2020.02.002" @default.
- W3023984985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32371023" @default.
- W3023984985 hasPublicationYear "2020" @default.
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