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- W3024018567 abstract "•The Cochrane Skin–Core Outcome Set Initiative (CS-COUSIN) is a multiprofessional international initiative that supports the development and implementation of the core outcome set (COS) in dermatology to improve and standardize outcome assessment in clinical trials and to make trial evidence more useful (www.cs-cousin.org). Within the CS-COUSIN, structured workflows have been established to ensure that the COS development is in accordance with current methodological standards. •There is a huge difference between “relevant” outcomes and CORE outcomes. In our experience, in many COS groups, at least 10, sometimes more than 30, outcome domains are “important”, but as few as necessary should be included into a COS to make it feasible and implementable. •Meaningful cross-trial comparisons usually require standardization at least up to the instrument level. In addition, it should be considered to standardize the crucial components of an outcome measure, that is, (1) concept to measure (reduction, response), (2) time of measurement, (3) analysis metric, (4) method of aggregation, and (5) statistical test procedures. •Whenever possible, we recommend to select only one measurement instrument for each core outcome domain or ideally one instrument that represents several more domains. For the latter, the profile could then be summarized in the quantitative analysis. •For implementation, in addition to the involvement of clinicians, researchers, industry representatives, and regulators, we encourage to also involve journal editors and trial registration bodies." @default.
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- W3024018567 date "2020-09-01" @default.
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- W3024018567 title "Controversy and Debate Series on Core Outcome Sets. Paper 6: Improving the generalizability, credibility and implementation of core outcome sets – the example of the Cochrane Skin-Core Outcome Set Initiative (CS-COUSIN)" @default.
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- W3024018567 doi "https://doi.org/10.1016/j.jclinepi.2020.05.016" @default.
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