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- W3024027510 abstract "We are grateful to Dorai, Pinto, and Cooper for their insightful Commentary on our manuscript ‘ The oncogenic transcription factor c-Jun regulates glutaminase expression and sensitizes cells to glutaminase-targeted therapy ’ (1,2). As summarized in the Commentary, glutaminase (GLS) catalyzes the first reaction of mitochondrial glutamine catabolism, generating glutamate and ammonia, and is overexpressed in a number of malignancies. Studies using small-molecule inhibitors or genetic approaches to suppress GLS have found that its activity can be important for cancer cell proliferation in vitro and for tumor growth in vivo . Indeed, the GLS inhibitor CB-839 is currently being evaluated in clinical trials for treatment of hematological cancers and triple-negative breast cancer (TNBC) (3,4). In our study, we found that c-Jun, which is up-regulated in TNBC as well as in a number of other human cancers, drives expression of the GLS gene and ultimately causes cancer cells to become dependent on the GLS reaction." @default.
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- W3024027510 date "2016-11-16" @default.
- W3024027510 modified "2023-09-26" @default.
- W3024027510 title "The regulation of cancer cell glutamine metabolism" @default.
- W3024027510 doi "https://doi.org/10.21037/10459" @default.
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