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• W3024107266 abstract "Background: Incompatibilities between the mother and unborn baby can cause complications that must be identified early to initiate the appropriate treatment. For example, neonatal alloimmune thrombocytopenia (NAIT), neonatal alloimmune neutropenia (NAIN), and morbus hemolyticus neonatorum affect children worldwide. Aim: This literature review aims to depict the similarities and differences between these three disorders from a clinical and mechanistic point of view. Material and Methods: The current literature review entailed conducting a systematic search to locate articles on the three conditions. Different electronic databases, including PsycINFO, PubMed, Web of Science, and CINAHL, were searched using the search terms “neonatal alloimmune thrombocytopenia”, “neonatal alloimmune neutropenia”, “morbus hemolyticus neonatorum”, “NAIT”, “FNAIT”, “fetal”, “NAIN”, and “hemolytic disease of the newborn”. Results: This review shows that these three diseases are caused by incompatibilities between the maternal and fetal immune systems. Furthermore, these conditions can lead to severe complications that hinder fetal development and cause death if not well managed. Discussion: The current literature review shows that NAIT, NAIN, and morbus hemolyticus neonatorum are rare conditions that occur when the mother produces antibodies against the fetal immune system. Thus, there is a need for the early detection of these conditions to initiate appropriate treatment before the child experiences adverse effects. Conclusion: The development of NAIT, NAIN, and morbus hemolyticus neonatorum is linked to the production of antibodies against the fetal immune system and fetal antigens. Further studies are required to determine potential interventions to reduce the risk of developing these three conditions." @default.
• W3024107266 created "2020-05-21" @default.
• W3024107266 creator A5017996365 @default.
• W3024107266 date "2020-05-14" @default.
• W3024107266 modified "2023-10-16" @default.
• W3024107266 title "Neonatal Immune Incompatibilities between Newborn and Mother" @default.
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• W3024107266 doi "https://doi.org/10.3390/jcm9051470" @default.
• W3024107266 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7291300" @default.
• W3024107266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32422924" @default.
• W3024107266 hasPublicationYear "2020" @default.
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