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• W3024134420 endingPage "947" @default.
• W3024134420 startingPage "931" @default.
• W3024134420 abstract "Abstract The germlines of metazoans contain transposable elements (TEs) causing genetic instability and affecting fitness. To protect the germline from TE activity, gonads of metazoans produce TE-derived PIWI-interacting RNAs (piRNAs) that silence TE expression. In Drosophila, our understanding of piRNA biogenesis is mainly based on studies of the Drosophila melanogaster female germline. However, it is not known whether piRNA functions are also important in the male germline or whether and how piRNAs are affected by the global genomic context. To address these questions, we compared genome sequences, transcriptomes, and small RNA libraries extracted from entire testes and ovaries of two sister species: D. melanogaster and Drosophila simulans. We found that most TE-derived piRNAs were produced in ovaries and that piRNA pathway genes were strongly overexpressed in ovaries compared with testes, indicating that the silencing of TEs by the piRNA pathway mainly took place in the female germline. To study the relationship between host piRNAs and TE landscape, we analyzed TE genomic features and how they correlate with piRNA production in the two species. In D. melanogaster, we found that TE-derived piRNAs target recently active TEs. In contrast, although Drosophila simulans TEs do not display any features of recent activity, the host still intensively produced silencing piRNAs targeting old TE relics. Together, our results show that the piRNA silencing response mainly takes place in Drosophila ovaries and indicate that the host piRNA response is implemented following a burst of TE activity and could persist long after the extinction of active TE families." @default.
• W3024134420 created "2020-05-21" @default.
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• W3024134420 creator A5053813994 @default.
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• W3024134420 date "2020-05-12" @default.
• W3024134420 modified "2023-10-17" @default.
• W3024134420 title "piRNA and Transposon Dynamics in Drosophila: A Female Story" @default.
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• W3024134420 cites W1511831772 @default.
• W3024134420 cites W1964854676 @default.
• W3024134420 cites W1964912817 @default.
• W3024134420 cites W1967090894 @default.
• W3024134420 cites W1969142635 @default.
• W3024134420 cites W1971549481 @default.
• W3024134420 cites W1972951765 @default.
• W3024134420 cites W1976342457 @default.
• W3024134420 cites W1981347911 @default.
• W3024134420 cites W1987256197 @default.
• W3024134420 cites W1990284991 @default.
• W3024134420 cites W1992532041 @default.
• W3024134420 cites W1997434013 @default.
• W3024134420 cites W1999901063 @default.
• W3024134420 cites W2000032214 @default.
• W3024134420 cites W2008951002 @default.
• W3024134420 cites W2009165504 @default.
• W3024134420 cites W2011378781 @default.
• W3024134420 cites W2023113177 @default.
• W3024134420 cites W2025964057 @default.
• W3024134420 cites W2030822261 @default.
• W3024134420 cites W2032621255 @default.
• W3024134420 cites W2034245741 @default.
• W3024134420 cites W2034573835 @default.
• W3024134420 cites W2038378062 @default.
• W3024134420 cites W2040409958 @default.
• W3024134420 cites W2041389096 @default.
• W3024134420 cites W2046318418 @default.
• W3024134420 cites W2057277929 @default.
• W3024134420 cites W2058689607 @default.
• W3024134420 cites W2059262955 @default.
• W3024134420 cites W2068711892 @default.
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• W3024134420 cites W2071501400 @default.
• W3024134420 cites W2077157705 @default.
• W3024134420 cites W2093113214 @default.
• W3024134420 cites W2104397965 @default.
• W3024134420 cites W2104582743 @default.
• W3024134420 cites W2107519392 @default.
• W3024134420 cites W2110187260 @default.
• W3024134420 cites W2117443539 @default.
• W3024134420 cites W2117833192 @default.
• W3024134420 cites W2119655133 @default.
• W3024134420 cites W2121332208 @default.
• W3024134420 cites W2122774081 @default.
• W3024134420 cites W2123489231 @default.
• W3024134420 cites W2124560890 @default.
• W3024134420 cites W2124985265 @default.
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• W3024134420 cites W2129449099 @default.
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• W3024134420 cites W2132989501 @default.
• W3024134420 cites W2138209388 @default.
• W3024134420 cites W2141696520 @default.
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• W3024134420 cites W2150158948 @default.
• W3024134420 cites W2154431984 @default.
• W3024134420 cites W2154872768 @default.
• W3024134420 cites W2157193551 @default.
• W3024134420 cites W2162946624 @default.
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• W3024134420 cites W2168585378 @default.
• W3024134420 cites W2169456326 @default.
• W3024134420 cites W2179438025 @default.
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• W3024134420 cites W2607476241 @default.
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• W3024134420 doi "https://doi.org/10.1093/gbe/evaa094" @default.
• W3024134420 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7337185" @default.
• W3024134420 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/32396626" @default.
• W3024134420 hasPublicationYear "2020" @default.
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